Table 3

Grey matter areas showing significant longitudinal differences in cortical thickness or thalamic nucleus volumes between PD patients with visual hallucinations (PD-VH) and those without hallucinations (PD non-VH)

Changes in cortical thickness
Tailarach coordinatesHemisphereAnatomical locationNumber of verticesSize (mm2)Zmax
xyz
28.1−20.837.8LPrecuneus368140.547.5
−32.755.414.2RCaudal anterior cingulate13656.877.4
2913.827.1RPrecentral14339.477.4
3.592.5−31RRostral middle frontal11557.257.3
27.7−66.528.8LSuperior frontal13455.167.2
−1629.5−12.3LInsula18445.627.1
−20.4−1142.5LPostcentral11329.177.1
−15.828.4−31.5LInsula343136.587
5.767.630.9LSuperior frontal19698.746.9
22.812.3−5.5RPostcentral12631.916.7
−30.242.541.1RSuperior frontal5327.296.7
38.148.9−28.4LRostral anterior cingulate5029.986.6
16.725.3−27.5RInsula15257.936.6
28.3−29.131.3RSupramarginal9124.736.6
35.80.525.4RPostcentral8422.186.4
3.5−86.9−28.8RLateral occipital199.096.3
30.224.738.3LSuperior frontal5015.036.1
−33.562.64.4RCaudal anterior cingulate5029.736.1
39.4−7−29.4RSuperior temporal299.066.1
−493.4−27.3LRostral middle frontal4121.086
−27.736.111.5LPrecentral259.545.9
Changes in thalamic subnucleus volume
Thalamic subnucleusHemisphereBetaP valueQ value
Mediodorsal medial magnocellularR−0.0370.0020.05
ParacentralL−0.0169.85E-06<0.001
  • Anatomical locations extracted from aparc freesurfer annotation.

  • Zmax indicates the −log10 (p value) for the cluster, a threshold of 5.613 was calculated to represent false discover rate (FDR) corrected values p<0.05 for both hemispheres.

  • No statistically changes were seen at baseline imaging between PD-VH and PD non-VH participants.

  • L, left; PD, Parkinson’s disease; R, right.VH, visual hallucination;