Baseline FRS scores according to CDR+NACC FTLD severity level, by genetic group
| CDR+NACC FTLD Global Group | GRN mutation carriers | MAPT mutation carriers | C9orf72 mutation carriers | Controls | ||||||
| 0 | 0.5 | ≥1 | 0 | 0.5 | ≥1 | 0 | 0.5 | ≥1 | ||
| N | 114 | 25 | 48 | 42 | 13 | 22 | 92 | 32 | 69 | 268 |
| FRS % Score | 97.4 (5.7) | 90.9† (14.2) | 46.3*, †, ‡ (28.1) | 93.0 (11.2) | 89.7 (18.9) | 43.0*, †, ‡ (27.1) | 94.9 (8.2) | 85.0*, † (20.2) | 32.7*, †, ‡ (25.0) | 96.2 (7.7) |
| CDR+NACC FTLD Sum of Boxes | 0.0 (0.0) | 1.0*, † (0.8) | 9.7*, †, ‡ (6.2) | 0.0 (0.0) | 1.1 (0.8)*, † | 10.5*, †, ‡ (5.9) | 0.0 (0.0) | 1.1*, † (0.7) | 11.1*, †, ‡ (5.5) | 0.2 (0.6) |
Values are mean (SD) unless stated.
CDR+NACC FTLD=CDR Dementia Staging Instrument plus Behaviour and Language domains from the NACC FTLD module.
CDR+NACC FTLD sum of boxes scores are also shown in the same groups for comparison.
*P<0.05 versus controls.
†P<0.05 versus CDR+NACC-FTLD Global score=0 group (within the same genetic group).
‡P<0.05 versus CDR+NACC-FTLD Global score=0.5 group (within the same genetic group).
CDR, Clinical Dementia Rating; FRS, Frontotemporal dementia Rating Scale; FTLD, Frontotemporal Lobar Degeneration; NACC, National Alzheimer’s Disease Coordinating Center.