Table 2

Group comparison between HC and patients who were AQP4-IgG and MOG-IgG seropositive at baseline (Spectralis devices only)

HCAQP4-IgGMOG-IgGAQP4-IgG vs HCAQP4-IgG vs MOG-IgGMOG-IgG vs HC
BSEPBSEPBSEP
Number of eyes14831755
pRNFL in
µm (mean±SD)
99.17±9.7678.46±24.1374.33±23.44−20.222.86<0.0010.344.330.937−29.402.75<0.001
mRNFL in
µm (mean±SD)
35.25±3.1328.09±6.6027.62±5.43−6.120.69<0.001−0.151.380.913−6.980.66<0.001
GCIP in
µm (mean±SD)
80.62±6.1465.81±13.0366.16±11.85−14.741.45<0.001−2.182.950.461−15.161.33<0.001
INL in
µm (mean±SD)
39.64±2.5139.85±3.5741.55±4.140.340.390.384−1.930.870.0281.790.530.001
OPL in
µm (mean±SD)
24.58±1.6425.02±2.0325.10±2.000.280.240.241−0.210.440.634−0.010.290.986
ONL in
µm (mean±SD)
63.59±5.7861.63±7.0464.71±7.87−0.010.830.993−1.771.800.3270.690.930.457
OPNL in
µm (mean±SD)
89.23±6.9586.65±7.2189.81±8.61−0.410.850.634−1.541.850.406−0.140.930.878
PR in
µm (mean±SD)
80.80±2.3880.35±2.9481.49±3.59−0.300.330.363−0.070.680.9230.200.390.610
RT in
µm (mean±SD)
324.47±13.24300.76±20.11306.6±17.99−20.162.37<0.001−6.614.770.169−18.912.49<0.001
  • AQP4-IgG, anti-aquaporin-4 antibody; B, estimate; GCIP, ganglion cell and inner plexiform layer; HC, healthy control; INL, inner nuclear layer; MOG-IgG, anti-myelin-oligodendrocyte-glycoprotein antibody; mRNFL, macular retinal nerve fibre layer; ONL, outer nuclear layer; OPL, outer plexiform layer; OPNL, outer plexiform and nuclear layer; PR, photoreceptor layer; pRNFL, peripapillary retinal nerve fibre layer; RT, total retinal thickness.