Table 1

Patient characteristics

Baseline characteristicsTotal (n=202)With NP symptoms (n=112)Without NP symptoms (n=90)P value
Male sex, n (%)115 (56.9)64 (57)51 (56.7)0.946
Age, mean (SD)65.0 (14.3)66.8 (14.1)62.7 (14.3)0.051
NIHSS score, median (IQR)8 (3.8–16)9 (4–16)7 (3–13.2)0.039
ICH volume*, median (IQR)8.3 (2.1–20)7.6 (1.9–19.8)8.9 (2.2–20.2)0.858
Lobar ICH location, n (%)72 (35.6)39 (34.8)33 (36.7)0.786
Right side ICH, n (%)99 (49.0)59 (52.7)40 (44.4)0.245
Previous conditions
Hypertension, n (%)128 (63.4)74 (66.1)54 (60.0)0.373
Hypercholesterolaemia, n (%)65 (32.2)36 (32.1)29 (32.2)0.990
Diabetes, n (%)29 (14.4)15 (13.4)14 (15.6)0.663
Excessive alcohol consumption, n (%)60 (29.7)33 (29.5)27 (30.0)0.934
Previous IS or ICH, n (%)25 (12.4)13 (11.6)12 (13.3)0.711
Pre-existing dementia,† n (%)19 (9.4)14 (12.5)5 (5.6)0.089
Pre-ICH functional disability,‡ n (%)29 (14.4)18 (16.1)11 (12.2)0.438
Follow-up features
Post-ICH dementia, n (%)48 (23.8)36 (32.1)12 (13.3)0.002
Antidepressant drug use, n (%)51 (25.2)33 (29.5)18 (20.0)0.135
Anxiolytic/hypnotic drug use, n (%)51 (25.2)30 (26.8)21 (23.3)0.606
MRI featuresTotal (n=167)With NP symptoms (n=94)Without NP symptoms (n=73)P value
Presence of lacunes, n (%)68 (40.7)37 (39.4)31 (42.5)0.685
Presence of superficial cortical siderosis27 (16.2)17 (18.1)10 (13.7)0.427
Presence of CMB, n (%)102 (61.1)62 (66.0)40 (54.8)0.142
Strictly lobar27 (16.2)19 (20.2)8 (11.0)0.107
Strictly deep17 (10.2)13 (13.8)4 (5.5)0.077
Mixed lobar+ deep58 (34.7)30 (31.9)28 (38.4)0.386
WMH Fazekas MRI score, n (%)
025 (15.0)13 (13.8)12 (16.4)0.639
142 (25.1)24 (25.5)18 (24.7)0.897
258 (34.7)32 (34.0)26 (35.6)0.832
342 (25.1)25 (26.6)17 (23.3)0.625
Cerebral atrophy MRI score, n (%)
032 (19.2)16 (17.0)16 (21.9)0.425
157 (34.1)34 (36.2)23 (31.5)0.528
270 (41.9)40 (42.6)30 (41.1)0.850
38 (4.8)4 (4.3)4 (5.5)0.964
CAA MRI profile, n (%)34 (20.4)17 (18.1)17 (23.3)0.408
  • *Expressed in mL.

  • †Defined as an Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) score ≥64.

  • ‡Defined as an mRS score ≥3.

  • CAA, cerebral amyloid angiopathy; CMB, cerebral microbleeds; ICH, intracerebral haemorrhage; IQR, interquartile range; IS, ischaemic stroke; MRI, magnetic resonance imaging; mRS, modified Rankin Scale; NIHSS, National Institute of Health Stroke Scale; NP, neuropsychiatric; SD, standard deviation; WMH, white matter hyperintensities.