Table 4

Determinants of mRS score reduction (n=216)

	mRS score reduction (shift analysis)
	Univariable			Multivariable*
	OR	95% CI	P value	OR	95% CI	P value
Age (years)
<60		Ref			Ref
≥60	0.39	0.22 to 0.69	0.001	0.31	0.15 to 0.66	0.003
Sex
Female		Ref			Ref
Male	1.11	0.67 to 1.86	0.682
Race
African-American		Ref			Ref
Caucasian	1.57	0.84 to 2.92	0.157
Others	0.86	0.41 to 1.80	0.688
Comorbidities
Smoking	0.63	0.25 to 1.58	0.323
Atrial fibrillation	1.38	0.69 to 2.79	0.365
Prior anticoagulation	1.42	0.53 to 3.79	0.483
Coronary artery disease	1.00	0.52 to 1.92	0.990
Congestive heart failure	0.79	0.40 to 1.57	0.500
Diabetes mellitus	0.44	0.26 to 0.74	0.002	0.47	0.23 to 0.94	0.032
Hypertension	0.56	0.29 to 1.06	0.074	0.66	0.29 to 1.49	0.315
Hyperlipidaemia	1.04	0.61 to 1.77	0.880
Previous stroke	1.11	0.59 to 2.08	0.745
Chronic kidney disease	1.01	0.52 to 1.93	0.987
Admission NIHSS (one unit)	0.89	0.86 to 0.93	<0.001	0.91	0.87 to 0.96	<0.001
Large vessel occlusion	0.34	0.19 to 0.59	<0.001	0.52	0.23 to 1.20	0.124
Stroke aetiology
Cardioembolism		Ref			Ref
CS/ESUS	1.23	0.59 to 2.56	0.576	1.19	0.52 to 2.73	0.685
Large-artery atherosclerosis	0.98	0.36 to 2.67	0.964	0.89	0.29 to 2.77	0.843
Small-vessel occlusion	2.92	0.99 to 8.59	0.052	2.98	0.71 to 12.44	0.131
Labs
NLR (one unit)	0.92	0.86 to 0.98	0.007	0.95	0.91 to 0.99	0.008
D dimer (µ100 ng/mL)	0.99	0.99 to 1.00	0.081	0.99	0.98 to 1.00	0.093
Absolute lymphocyte (1000/µL)	1.00	0.99 to 1.01	0.804
Platelets	1.00	1.00 to 1.00	0.536
IV tPA	1.60	0.86 to 2.97	0.137
Thrombectomy	1.04	0.55 to 1.98	0.898
sICH	0.23	0.07 to 0.76	0.015	0.18	0.04 to 0.73	0.016

Univariable and multivariable mixed effects ordinal logistic regression analyses were done to test for the impact of several determinants on a reduction of mRS score and a decrease in disability. Variables that had a p<0.1 were included in the final multivariable model.
*The results after multiple imputation using chained equations to handle missing data.
CS/ESUS, cryptogenic stroke/embolic stroke of undetermined source; NIHSS, National Institutes of Health Stroke Scale; NLR, neutrophil–lymphocyte ratio; sICH, symptomatic intracranial haemorrhage; IV tPA, intravenous tissue plasminogen activator.