Detailed characteristics of included cohorts
| Characteristics | All cohorts (N=100) | Natural history (n=25) | Surgery (n=52) | Radiosurgery (n=23) | ||||||||
| Cohorts, n (%) | Sample size* | Mean† (range‡) | Cohorts, n (%) | Sample size* | Mean† (range‡) | Cohorts, n (%) | Sample size* | Mean† (range‡) | Cohorts, n (%) | Sample size* | Mean† (range‡) | |
| Prospective design | 15 (15) | 2463 | NA | 12 (48) | 2093 | NA | 2 (4) | 72 | NA | 1 (4) | 298 | NA |
| Age (years) | 95 (95) | 8679 | 36.63 (7⎯58) | 24 (96) | 3455 | 38.27 (10⎯54) | 50 (96) | 3302 | 34.86 (7.1⎯58) | 22 (95) | 1922 | 38.95 (34⎯43.7) |
| Male gender | 96 (96) | 4436 | 46 (5⎯324) | 24 (96) | 1812 | 76 (11⎯324) | 50 (96) | 1672 | 33 (7⎯104) | 22 (95) | 952 | 43 (5⎯141) |
| CCM size (cm) | 45 (45) | 4808 | 1.78 (0.85⎯3.3) | 13 (52) | 2129 | 1.46 (0.85⎯2) | 29 (56) | 2256 | 1.96 (1.35⎯3.3) | 3 (13) | 423 | 1.4 (1.31⎯1.48) |
| Multiple CCMs | 70 (70) | 1194 | 17 (0⎯133) | 19 (76) | 678 | 36 (0⎯133) | 38 (73) | 308 | 8 (0⎯53) | 16 (70) | 208 | 16 (0⎯76) |
| Presentation | ||||||||||||
| Initial ICH | 98 (98) | 6314 | 64 (0⎯690) | 25 (100) | 2008 | 80 (0⎯690) | 50 (96) | 2502 | 50 (0⎯260) | 23 (100) | 1804 | 78.43 (0⎯261) |
| Localisation | ||||||||||||
| Lobar | 95 (95) | 2921 | 31 (0⎯290) | 21 (84) | 1466 | 70 (0⎯290) | 52 (100) | 954 | 18 (0⎯168) | 22 (95) | 501 | 23 (0⎯115) |
| Deep-seated | 94 (94) | 1094 | 12 (0⎯121) | 20 (80) | 422 | 21 (0⎯121) | 52 (100) | 401 | 8 (0⎯72) | 22 (95) | 271 | 12 (0⎯55) |
| Brainstem | 95 (95) | 4607 | 48 (0⎯708) | 21 (84) | 1560 | 74 (0⎯708) | 52 (100) | 1919 | 37 (0⎯260) | 22 (95) | 1128 | 51 (0⎯155) |
| Cerebellum | 93 (93) | 344 | 4 (0⎯58) | 19 (76) | 115 | 6 (0⎯22) | 52 (100) | 106 | 2 (0⎯58) | 22 (95) | 123 | 5 (0⎯41) |
| Follow-up (months) | 98 (98) | 8856 | 49.15 (5⎯115.2) | 25 (100) | 3573 | 51.15 (11.2⎯104.4) | 51 (98) | 3339 | 43.9 (5⎯115.2) | 22 (95) | 1944 | 50.04 (23.6⎯112) |
*Total number of patients with available requested data.
†If mean was not available, median was used.
‡Data for the range in the following variables: age, CCM size and follow-up were derived from the mean values (and median, if mean was not available) within each study.
CCM, cerebral cavernous malformation; ICH, intracerebral haemorrhage; NA, not applicable.