Table 2

CAIDE score associations with progression of SVD markers

	Statistics	P value	FDR-corrected p value
White matter hyperintensities
Total	t=3.44	<0.001***	0.004**
Periventricular	t=3.72	<0.001***	0.004**
Deep	t=2.55	0.012*	0.043*
Frontal	t=3.52	<0.001***	0.004**
Temporal	t=0.51	0.609	0.760
Parietal	t=2.52	0.013*	0.043*
Occipital	t=1.75	0.082	0.164
Cerebral microbleeds
Whole brain	r_s=0.14	0.087	0.164
Lobar	r_s=0.13	0.113	0.193
Deep	r_s=0.06	0.458	0.649
Enlarged perivascular spaces
Centrum semiovale	t=−0.41	0.679	0.760
Basal ganglia	t=−0.37	0.715	0.760
Composite SVD scores
Global SVD	t=0.49	0.625	0.759
HA-SVD	t=−0.07	0.947	0.947
CAA-SVD	t=0.95	0.344	0.531
Inflammation
CRP	t=2.41	0.017*	0.049*
Fibrinogen	t=1.79	0.076	0.164

WMH and EPVS progression analysed using linear mixed-effects modelling; CMB progression analysed using Spearman’s correlation. Lacune progression not analysed due to low incidence of new lacunes.
*P<0.05, **p<0.01, ***p<0.001.
CAA, cerebral amyloid angiopathy; CAIDE, Cardiovascular Risk Factors, Ageing and Dementia; CMB, cerebral microbleeds; CRP, C reactive protein; EPVS, enlarged perivascular spaces; FDR, false discovery rate; HA, hypertensive arteriopathy; SVD, small vessel disease; WMH, white matter hyperintensities.