Characteristics of the study population
| All (N=608) | Collateral cohort (n=229) | Perfusion cohort (n=379) | ||
| Age (in years) | Mean (SD) | 67.4 (14.6) | 68.9 (14) | 66.5 (14.9) |
| Median (IQR) | 70 (21) | 70 (20) | 70 (22) | |
| Sex | Females | 307 (50.5%) | 122 (53.3%) | 185 (48.8%) |
| Males | 301 (49.5 %) | 107 (46.7%) | 194 (51.2%) | |
| NIHSS | Median (IQR) | 16 (9) | 15 (11) | 16 (10) |
| Time (min) median (IQR) | Onset/LKW to ED | 530 (290) | 555 (278) | 515 (295) |
| ED to imaging | 30 (25) | 28 (34) | 30 (24) | |
| Imaging to puncture | 65 (70) | 106 (115) | 60 (58) | |
| Puncture to reperfusion | 35 (40) | 24 (23) | 45 (43) | |
| Onset/LKW to reperfusion | 684 (299) | 723 (281) | 648 (302) | |
| ED to reperfusion | 155 (102) | 182 (123) | 150 (90) | |
| Non-contrast ASPECTS | Median (IQR) | 8 (2) | 8 (2) | 8 (3) |
| ASPECTS 2–5, n (%) | 29 (4.8) | 6 (2.6) | 23 (6.1) | |
| ASPECTS 6, n (%) | 50 (8.2) | 20 (8.8) | 30 (7.9) | |
| ASPECTS 7, n (%) | 121 (19.9) | 48 (21.1) | 73 (19.3) | |
| ASPECTS 8, n (%) | 151 (24.9) | 67 (29.4) | 84 (22.2) | |
| ASPECTS 9, n (%) | 121 (19.9) | 52 (22.8) | 69 (18.2) | |
| ASPECTS 10, n (%) | 135 (22.2) | 35 (15.4) | 100 (26.4) | |
| Imaging | mCTA, n (%) | 394 (64.8) | 192 (83.8) | 202 (53.3) |
| CTP, n (%) | 379 (63.3) | N/A | ALL | |
| Favourable CTP profile | 339 (89.5% of all CTP) | N/A | 339 (89.5%) | |
| Favourable collateral profile | 544 (90.1%) | 195 (86.3%) | 349 (92.3%) | |
| Occlusion site | Terminal ICA, n (%) | 136 (22.4) | 49 (21.4) | 87 (23) |
| M1-MCA, n (%) | 3767 (60.4) | 144 (62.9) | 223 (58.8) | |
| M2-MCA, n (%) | 82 (13.5) | 19 (8.3) | 63 (16.6) | |
| Tandem cervical ICA | 112 (18.4%) | 36 (15.7%) | 76 (20.1%) | |
| Intravenous alteplase administration | 55 (9.1%) | 19 (8.3%) | 36 (9.5%) | |
| Final TICI | 2b–3, n (%) | 493 (81.2) | 199 (86.9) | 294 (77.8) |
| Symptomatic ICH* | n (%) | 70 (12.4) | 36 (18.8) | 34 (9.2) |
| 90-day mRS | Median (IQR) | 3 (4) | 3 (4) | 3 (3) |
| 0–1, n (%) | 171 (29.3)* | 66 (30.8)** | 105 (28.5)*** | |
| 0–2, n (%) | 262 (44.9)* | 94 (43.9)** | 168 (45.5)*** | |
| Mortality, n (%) | 102 (17.5)* | 44 (20.6)** | 58 (15.7)*** | |
*Of 583 patients, **of 214 patients, ***of 369 patients *defined using the European–Australian Cooperative Acute Stroke Study 2 definition.
ASPECTS, Alberta Stroke Program Early CT Score; CTP, CT perfusion; ED, emergency department; ICA, Internal Carotid Artery; ICH, intracranial haemorrhage; LKW, last-known-well; MCA, middle cerebral artery ; mCTA, multiphase CT angiography; mRS, modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; sCTA, single-phase CT angiography; TICI, thrombolysis in cerebral ischaemia.