Table 3

3-month outcomes according to stroke aetiology

A. all 3-month outcomes stratified to stroke etiology
3-month outcomeAll (N=2082)*N missingStroke etiology
Competing mechanism (N=533)Insufficient anticoagulation (N=729)Cardioembolism despite sufficient anticoagulation (N=820)
composite outcome, N (%)516 (27.1%)176125 (25.4%)186 (27.8%)205 (27.5%)
recurrent ischemic stroke, N (%)84 (4.6%)24033 (6.8%)23 (3.6%)28 (3.9%)
intracranial hemorrhage, N (%)15 (0.8%)2383 (0.6%)6 (0.9%)6 (0.8%)
all-cause death, N (%)434 (22.8%)17793 (18.9%)164 (24.5%)177 (23.8%)
mRS ≥3, N (%)1,081 (56.7%)177258 (52.5%)421 (62.9%)402 (54.0%)
B. Association of stroke etiology with the primary and secondary endpoint
Stroke etiologyComposite outcomeRecurrent ischemic stroke
unadjustedadjusted†unadjustedadjusted†
OR [95%CI]p valueN events/ total N in modelaOR [95%-CI]p valueN events/ total N in modelOR [95%-CI]p valueN events/ total N in modelaOR [95%-CI]p valueN events/ total N in model
competing stroke mechanism0.90 (0.69 to 1.16)0.4516/19061.18 (0.83 to 1.66)0.363473/17731.80 (1.07 to 3.02)0.02684/18421.83 (1.05 to 3.20)0.03477/1697
insufficient anticoagulation1.02 (0.81 to 1.28)0.8910.93 (0.68 to 1.27)0.6480.91 (0.52 to 1.60)0.7510.99 (0.55 to 1.79)0.968
cardioembolism despite sufficient anticoagulation(reference)(reference)(reference)(reference)
  • *Adjusted for age, sex, hypertension, diabetes, ischaemic heart disease, dyslipidaemia, renal impairment, prior ischaemic stroke, intracranial haemorrhage, current smoking and active malignancy.

  • †3-month outcomes not collected in the centres Berlin, Heidelberg and Mainz.

  • aOR, adjusted OR; mRS, modified Rankin Scale.