Descriptive comparison of iatrogenic cases of CAA reported to date, compared with typical features of sporadic CAA
| Iatrogenic cases (n=23) | Sporadic CAA | References | ||
| Age at first presentation | Mean 37.7 years | Associated with increasing age; rare in those under 60 years; current diagnostic criteria state age >55 years | 23 44 45 | |
| Sex | 73.9% cases male | Pathologically more common in women; women more likely to have lobar ICH | 44 46 | |
| ApoE genotype | ε3 present in all cases; homozygous in 66.7% | Usually associated with ε2 and ε4 genotypes | 45 47 | |
| Associated symptoms | ICH | 87.0% cases | Well recognised | 18 |
| Recurrent ICH | 65.2% cases | Well recognised; annual recurrence risk 7.4% (compared with 1.1% for non-CAA ICH) | 18 48 | |
| Cognitive impairment | 39.1% cases | Well recognised | 18 | |
| TFNE | 1 case | Well recognised | 9 18 | |
| Seizures | 26.1% cases | Can occur but frequency unknown; recognised feature of CAA-related inflammation | 18 | |
ApoE, apolipoprotein E; CAA, cerebral amyloid angiopathy; ICH, intracerebral haemorrhage; TFNE, transient focal neurological episodes ('amyloid spells').