Table 1

Data-derived clusters compared with LRRK2 and GBA mutation status

LRRK2GBA
Non-carriersCarriersNon-carriersE326K and T369M carriersGD-causing variants
Tracking Parkinson’s cohort
Cluster 1469 (99.8%)1 (0.2%)Cluster 1437 (91.8%)29 (6.1%)10 (2.1%)
Cluster 2432 (99.1%)4 (0.9%)Cluster 2413 (93.7%)20 (4.5%)8 (1.8%)
Cluster 3314 (98.1%)6 (1.9%)Cluster 3282 (87.0%)27 (8.3%)15 (4.6%)
Cluster 4304 (99.7%)1 (0.3%)Cluster 4280 (90.9%)20 (6.5%)8 (2.6%)
P=0.059P=0.080
P value (GBA variants combined)=0.018
Oxford discovery cohort
Cluster 1280 (99.3%)2 (0.7%)Cluster 1231 (90.9%)15 (5.9%)8 (3.2%)
Cluster 2150 (98.7%)2 (1.3%)Cluster 2127 (93.4%)8 (5.9%)1 (0.7%)
Cluster 3204 (100%)0Cluster 3158 (88.8%)14 (7.9%)6 (3.4%)
Cluster 4221 (99.1%)2 (0.9%)Cluster 4185 (90.7%)16 (7.8%)3 (1.5%)
P=0.45P=0.57
P value (GBA variants combined)=0.59
Combined cohort
Combined cohort p=0.35Combined cohort p=0.036
Combined cohort p value (GBA variants combined)=0.009
  • Note the numbers in this table are slightly different to the numbers in the other analyses since the mutation status did not come from the imputed array data.

  • GBA, glucocerebrosidase; GD, Gaucher’s disease; LRRK2, leucine-rich repeat kinase 2.