Table 1

Characteristics of the mothers, their treatment and breast milk rituximab concentrations

Patient 1Patient 2Patient 3Patient 4Patient 5Patient 6
Rituximab infusions prior delivery, no220312
Time from last infusion to delivery, months1112.410.71210.4
Time after delivery to infusion, days132023302631
Rituximab dose, mg5005001000500500500
AUC0 – Tmax, µg.d/mL1.933.555.324.563.404.75
Cavg, µg/mL0.0170.0310.0480.0410.0350.043
Cmax, µg/mL0.090.10.250.10.20.12
Average daily infant dose, µg/kg/day2.584.757.256.225.256.42
Absolute maximum daily infant dose, µg/kg/day13.51537.5153018.5
RID from Cavg, %0.0360.0670.0510.0870.0740.090
RID from Cmax, %0.190.210.260.210.420.26
Timing of samples after infusion, day0, 2, 9, 22, 66, 1120, 2, 8, 22, 67, 1120, 4, 8, 22, 64, 1100, 2, 8, 22, 69, 1100, 3, 7, 21, 66, 970, 3, 8, 27, 84, 111
  • AUC, area under the curve; Cavg, average rituximab concentration measured in breast milk; Cmax, maximum rituximab concentration measured in breast milk post infusion; RID, relative infant dose.