All-cause mortality risk in relapsing-remitting multiple sclerosis by period of diagnosis, sex, age at onset and diagnostic delay
| HR | 95% CI | P value | |
| Period of diagnosis | |||
| <1980 | 2.4 | 1.94 to 3.05 | <0.001 |
| 1980–1989 | 1.7 | 1.30 to 2.10 | <0.001 |
| 1990–1999 | Reference | – | – |
| 2000–2019 | 0.49 | 0.34 to 0.70 | <0.001 |
| Sex | |||
| Women | Reference | ||
| Men | 1.4 | 1.18 to 1.59 | <0.001 |
| Age at onset | |||
| <20 | Reference | – | – |
| 20–29 | 1.4 | 1.07 to 1.88 | 0.016 |
| 30–39 | 1.9 | 1.44 to 2.58 | <0.001 |
| 40–49 | 3.2 | 2.33 to 4.52 | <0.001 |
| ≥50 | 8.5 | 5.83 to 12.39 | <0.001 |
| Diagnostic delay | |||
| <2 years | Reference | – | – |
| 2–4 years | 1.4 | 1.13 to 1.74 | 0.002 |
| 5–10 years | 1.7 | 1.34 to 2.05 | <0.001 |
| >10 years | 2.7 | 2.25 to 3.34 | <0.001 |