All-cause standardised mortality ratios (SMRs) and excess death rates (EDRs) among persons with multiple sclerosis in Hordaland and Møre and Romsdal counties, Western Norway
| Observed | Expected | SMR (95% CI) | EDR (95% CI) | |
| Sex | ||||
| Female | 535 | 218.3 | 2.5* (2.25 to 2.67) | 6.1 (5.75 to 6.46) |
| Male | 429 | 205.4 | 2.1* (1.90 to 2.30) | 7.9 (7.22 to 8.60) |
| Course of disease | ||||
| PPMS† | 237 | 92.3 | 2.6* (2.25 to 2.92) | 14.5 (13.24 to 15.60) |
| RRMS‡ | 715 | 327.3 | 2.2* (2.03 to 2.35) | 5.6 (5.28 to 5.98) |
| Unknown | 12 | N/A | N/A | N/A |
| Age at onset | ||||
| <20 | 68 | 17.8 | 3.8* (2.96 to 4.84) | 6.4 (5.77 to 6.86) |
| 20–29 | 306 | 102.7 | 3.0* (2.66 to 3.33) | 6.9 (6.47 to 7.25) |
| 30–39 | 303 | 134.4 | 2.3* (2.01 to 2.52) | 6.7 (6.04 to 7.24) |
| 40–49 | 169 | 93.9 | 1.8* (1.54 to 2.09) | 6.0 (4.78 to 7.05) |
| ≥50 | 118 | 74.8 | 1.6* (1.31 to 1.89) | 9.2 (6.03 to 11.79) |
| Period of onset | ||||
| <1950 | 141 | 63.7 | 2,2* (1.86 to 2.61) | 13.5 (11.52 to 15.22) |
| 1950–1959 | 116 | 55.4 | 2.1* (1.73 to 2.51) | 13.6 (11.07 to 15.61) |
| 1960–1969 | 147 | 58.6 | 2.5* (2.12 to 2.95) | 12.3 (10.85 to 13.48) |
| 1970–1979 | 235 | 72.8 | 3.2* (2.83 to 3.67) | 12.9 (12.13 to 13.61) |
| 1980–1989 | 187 | 82.5 | 2.3* (1.95 to 2.61) | 6.3 (5.50 to 6.93) |
| 1990–1999 | 99 | 53.3 | 1.9* (1.51 to 2.26) | 2.9 (2.19 to 3.54) |
| 2000–2015 | 39 | 36.0 | 1.1 (0.77 to 1.48) | 0.2 (-0.62 to 0.76) |
| Period of diagnosis | ||||
| <1980 | 475 | 177.5 | 2.7* (2.44 to 2.93) | 15.8 (14.94 to 16.65) |
| 1980–1989 | 249 | 97.2 | 2.6* (2.25 to 2.90) | 10.3 (9.39 to 11.03) |
| 1990–1999 | 152 | 73.3 | 2.1* (1.76 to 2.43) | 4.4 (3.66 to 4.95) |
| 2000–2019 | 88 | 75.7 | 1.2 (0.93 to 1.43) | 0.4 (–0.19 to 0.94) |
| Total | 964 | 423.6 | 2.3* (2.13 to 2.42) | 6.8 (6.42 to 7.09) |
*p < 0.001.
†Primary progressive multiple sclerosis.
‡Relapsing-remitting multiple sclerosis.
EDR, excess death rates; SMR, standardised mortality ratios.