Table 4

Regional associations of reduced functional connectivity with primary motor cortex neurochemistry and FA

Group comparisonBrain region
(Brodmann area)
Brodmann areaType of associationT -value
Associations between reduced FC and tNAA/Cr ratios
ALS<HCL primary sensory cortexBA 1Positive5.09
R primary motor cortexBA 44.55
B premotor+supplementary motor areaBA 64.44
R putamen4.10
R temporal pole3.82
ALS<HCR inferior frontal gyrusBA 47Negative−4.12
Associations between reduced FC and WM FA—no suprathreshold clusters
  • T values and coordinates in MNI standard space are reported (T; x, y, z).

  • ALS, amyotrophic lateral sclerosis; B, bilateral; Cr, creatine; FA, fractional anisotropy; FC, functional connectivity; L, left; R, right; tNAA, total N-acetyl aspartate moieties.