Table 3

Summary of structural and neurochemical measures in the PMC

Imaging metricMean±SEp-value
ALSHC
Neurochemical ratios
 tNAA/Cr1.88±0.032.05±0.03<0.001
 tNAA/Cho2.44±0.142.94±0.140.017
Diffusion in PMC WM
 FA0.38±0.000.41±0.00<0.001
 MD(0.80±0.01)(0.77±0.01)<0.001
 RD(0.64±0.01)(0.6±0.01)0.022
 AD(1.12±0.01)(1.12±0.01)NS
  • MD, RD, AD are ×10−3 mm2/s. The boldened p-values indicate statistically significant group differences.

  • AD, axial diffusivity; Cho, choline; Cr, creatine; FA, fractional anisotropy; MD, mean diffusivity; PMC, primary motor cortex; RD, radial diffusivity; tNAA, total NAA moieties; WM, white matter.