Comparison of diagnostic sensitivity of the WHO and 2017 EU criteria and RT-QuIC alone among sCJD subtypes
| MM(V)1 (n=205) | VV2 (n=40) | MV2K (n=30) | MM(V)2C (n=11) | |
| Updated WHO criteria | 163/205 79.5%* | 30/40 75% | 17/30 56.7% | 7/11 63.6% |
| 2017 EU criteria | 201/205 98.0% | 39/40 97.5% | 30/30 100% | 11/11 100% |
| RT-QuIC alone, overall | 193/205 94.1% | 38/40 95.0% | 30/30 100% | 10/11 90.9% |
| RT-QuIC alone, PQ-CSF | 151/175 86.3% | 28/34 82.3% | 22/26 84.6% | 8/10 80% |
| RT-QuIC alone, IQ-CSF | 109/118 92.4% | 32/32 100% | 21/21 100% | 7/7 100% |
Eleven patients were not included because the available brain tissue was insufficient to complete histotyping. Only p values of statistically significant comparisons are shown. Patients classified as ‘probable sCJD’ are considered ‘true positive’ in the different criteria' sensitivity calculation.
*Compared with MV2K, p=0.01.
CSF, cerebrospinal fluid; EU, European Union; RT-QuIC, real-time quaking-induced conversion assay; sCJD, sporadic Creutzfeldt-Jakob disease.