Demographic overview
| HC | NMOSD-NON | NMOSD-ON | |
| Subjects (n) | 62 | 45 | 28 |
| Eyes (n) | 124 | 90 | 56 |
| Patients with a disease duration <10 years (n) | . | 43 | 21 |
| Patients with ON as first manifestation (n) | . | . | 17 |
| Age (year, mean±SD) | 37.7±10.2 | 39.0±10.4 | 38.8±12.1 |
| Sex (male, n (%)) | 20 (32) | 2 (4) | 3 (11) |
| Time since ON (year, median (min−max)) | . | . | 2.8 (0.7–19.5) |
| Time since onset (year, mean±SD) | . | 3.8±4.0 | 6.5±5.6 |
| pRNFL thickness (µm, mean±SD) | 98.5±9.4 | 98.8±10.8 | 80.7±24.9 |
| pRNFL IEPD (%, mean±SD) | 2.7±2.3 | 3.7±4.4 | 28.6±19.9 |
| pRNFL IEAD (µm, mean±SD) | 2.7±2.2 | 3.8±4.5 | 27.0±19.8 |
| GCIPL thickness (µm, mean±SD) | 79.9±5.3 | 77.6±6.3 | 66.3±13.2 |
| GCIPL IEPD (%, mean±SD) | 1.3±1.1 | 2.7±3.5 | 19.0±14.3 |
| GCIPL IEAD (µm, mean±SD) | 1.0±0.9 | 2.1±2.9 | 14.1±10.9 |
GCIPL, combined ganglion cell and inner plexiform layer; HC, healthy control; IEAD, intereye absolute difference; IEPD, intereye percentage difference; NMOSD-NON, patients with aquaporin-4-antibody seropositive neuromyelitis optica spectrum disorders and no history of optic neuritis; NMOSD-ON, patients with aquaporin-4-antibody seropositive neuromyelitis optica spectrum disorders and a history of unilateral optic neuritis; ON, optic neuritis; pRNFL, peripapillary retinal nerve fibre layer.