Multivariate Cox regression analysis for plasma p-tau181 and clinical prognostic factors in ALS
| Variable | HR (95% CI) | P value | |
| Plasma p-tau181 | 1.90 (1.25 to 2.90) | 0.003 | |
| Age at onset disease | 1.02 (0.99 to 1.04) | 0.08 | |
| Onset type | Spinal | Ref | Ref |
| Bulbar | 2.22 (1.11 to 4.42) | 0.024 | |
| Pyramidal | 0.33 (0.92 to 1.19) | 0.09 | |
| Pseudopolyneuritic | 0.35 (0.09 to 1.49) | 0.15 | |
| ALSFRS-R scale | 0.96 (0.92 to 1.001) | 0.06 | |
| FTD status | 1.95 (0.86 to 4.46) | 0.11 | |
| King’s score | 1.72 (0.99 to 2.97) | 0.053 | |
| b-DPR | Slow progressors | Ref | Ref |
| Intermediate progressors | 2.49 (1.35 to 4.61) | 0.004 | |
| Fast progressors | 5.16 (2.40 to 11.07) | <0.001 | |
ALS, amyotrophic lateral sclerosis; ALSFRS-R, Revised Amyotrophic Lateral Sclerosis Functional Rating; b-DPR, basal disease progression rate; FTD, frontotemporal dementia; p-tau181, phosphorylated tau 181; Ref, reference.