Table 2

Multiple sclerosis (MS) cohort compared with New Zealand population with standardised mortality ratios (SMR) and excess death rates (EDR)

GroupnObserved mortalityExpected mortalitySMREDRPatient years
MS cohort2909844 (29%)438 (15%)1.9 (1.8, 2.1)4.8 (4.4, 5.3)83 899
Sex
 Female2184600 (27%)316 (14%)1.9 (1.7, 2.1)4.4 (3.9, 5.0)64 308
 Male725244 (34%)122 (17%)2.0 (1.8, 2.3)6.2 (5.2, 7.4)19 591
Disease course
 Relapsing onset2386579 (24%)316 (13%)1.8 (1.7, 2.0)3.7 (3.3, 4.2)70 176
 Progressive onset459232 (51%)104 (23%)2.2 (2.0, 2.5)10.4 (8.7, 12.4)12 266
 Unknown6433 (52%)18 (28%)1.8 (1.3, 2.6)10.3 (5.8, 17.0)1457
Age at onset (years)
 0–2025161 (24%)24 (10%)2.5 (1.9, 3.3)3.9 (2.8, 5.4)9459
 21–30876193 (22%)70 (8%)2.8 (2.4, 3.2)4.3 (3.6, 5.1)28 595
 31–40937240 (26%)133 (14%)1.8 (1.6, 2.0)4.0 (3.3, 4.8)26 820
 41–79803321 (40%)194 (24%)1.7 (1.5, 1.8)6.7 (5.6, 7.9)19 026
 Unknown42
Age at diagnosis (years)
 1–208820 (23%)7 (8%)2.9 (1.7, 4.4)4.9 (2.6, 8.4)2653
 21–30586117 (20%)33 (6%)3.5 (2.9, 4.2)4.8 (3.9, 6.0)17 369
 31–40915219 (24%)93 (10%)2.4 (2.1, 2.7)4.7 (3.9, 5.6)26 962
 41–851286472 (37%)297 (23%)1.6 (1.4, 1.7)4.8 (4.1, 5.6)36 372
 Unknown34
Period of onset
 1941–196613088 (68%)62 (48%)1.4 (1.1, 1.7)3.6 (2.3, 5.2)7279
 1967–1976292157 (54%)78 (27%)2.0 (1.7, 2.4)6.0 (4.8, 7.5)13 072
 1977–1986541204 (38%)111 (21%)1.8 (1.6, 2.1)4.8 (3.9, 5.9)19 390
 1987–1996933232 (25%)106 (11%)2.2 (1.9, 2.5)5.0 (4.1, 5.9)25 430
 1997–2006971134 (14%)64 (7%)2.1 (1.8, 2.5)3.7 (2.9, 4.7)18 728
 Unknown42
Period of diagnosis
 1945–19663323 (70%)18 (55%)1.3 (0.8, 1.9)2.7 (0.9, 6.3)1848
 1967–197614094 (67%)44 (31%)2.1 (1.7, 2.6)7.8 (5.8, 10.3)6377
 1977–1986402203 (50%)107 (27%)1.9 (1.6, 2.2)6.1 (5.0, 7.5)15 614
 1987–1996844279 (33%)139 (16%)2.0 (1.8, 2.3)5.3 (4.5, 6.3)26 304
 1997–20061456229 (16%)122 (8%)1.9 (1.6, 2.1)3.2 (2.6, 3.9)33 214
 Unknown34