Table 1

Characteristics of studies included in the systematic review and meta-analysis

StudyRecruiting centresPeriod of enrolmentInclusion criteriaIncluded patients (N)EVTBMT
Years of ageNIHSS scorePrestroke mRS scoreStroke onsetLarge coreImaging used to evaluate ASPECTS
ANGEL-ASPECT4 ChinaOctober 2020–May 202218–806–300–1Within 24 hoursASPECTS 3–5
OR an ischaemic-core volume of 70 to 100
Non-contrast CT456231225
RESCUE-Japan LIMIT8 JapanNovember 2018–September 2021>18, no upper age limit≥6, no upper limit0–1Within 6 hours
or within 24 hours and no FLAIR early changes
ASPECTS 3–5Non-contrast CT or diffusion-weighted MRI203101102
SELECT25 InternationalSeptember 2019–September 202218–85≥6, no upper limit0–1Within 24 hoursASPECTS 3–5
or an ischaemic-core volume of at least 50 mL (no upper limit for volume of ischaemic core)
Non-contrast CT352178174
TESLA6 7 USAJuly 2019–October 202218–85≥6, no upper limit0–1Within 24 hoursASPECTS 2–5Non-contrast CT300152148
  • ANGEL-ASPECT, Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients With a Large Infarct Core; ASPECTS, Alberta Stroke Program Early CT Score; BMT, Best Medical Treatment; EVT, Endovascular Treatment; mRS, Modified Rankin Scale; NIHSS, National Institutes of Health Stroke Scale; RESCUE Japan-LIMIT, Recovery by Endovascular Salvage for Cerebral Ultra-acute Embolism Japan Large Ischemic core Trial; SELECT2, Randomised Controlled Trial to Optimize Patient Selection for Endovascular Treatment in Acute Ischemic Stroke; TESLA, Thrombectomy for Emergent Salvage of Large Anterior Circulation Ischemic Stroke.