Sample characteristics (A) and sample characteristics per cognitive domain analysis (B)
| A | ||
| PDP (n=2912) | PDnP (n=6056) | |
| Age, mean±SD | 68.92±4.34 | 66.88±4.28 |
| Education years, mean±SD | 11.29±3.52 | 11.12±3.54 |
| PD duration, mean±SD | 9.08±2.94 | 7.00±2.65 |
| Male, n (%) | 1404 (48.8) | 3460 (57.1) |
| LEDD, mean±SD | 644.94±223.82 | 570.21±220.83 |
| UPDRS (part III), mean±SD | 28.19±7.79 | 23.31±6.72 |
| B | ||||||||||
| Domain | PDP (n) | PD (n) | Age PDP (mean±SD) | Age PD (mean±SD) | UPDRS part III scores (PDP) (mean±SD) | UPDRS part III scores (PD) (mean±SD) | PD duration (years) (PDP) (mean±SD) | PD duration (years) (PD) (mean±SD) | LEDD mg/day (PDP) (mean±SD) | LEDD mg/day (PD) (mean±SD) |
| Attention | 571 | 1094 | 68.00±3.92 | 66.05±4.15 | 27.4±7.9 | 22.45±6.94 | 8.01±2.68 | 6.61±2.54 | 668.91±219.2 | 574.28±185.96 |
| Construction | 265 | 332 | 67.43±3.67 | 65.76±4.06 | 25.38±5.86 | 21.65±6.57 | 6.95±2.95 | 6.32±2.43 | 647.70±210.70 | 541.67±190.12 |
| Episodic memory | 775 | 1358 | 68.01±3.85 | 66.37±4.02 | 26.27±6.84 | 21.82±6.42 | 8.44±3.30 | 7.02±2.89 | 614.32±258.74 | 536.33±215.66 |
| Executive functions | 804 | 1399 | 68.55±4.17 | 66.62±4.14 | 26.82±7.71 | 22.18±6.87 | 8.46±3.31 | 7.16±3.07 | 612.86±243.97 | 536.45±232.50 |
| Global cognition | 2673 | 5862 | 68.74±4.15 | 66.87±4.25 | 27.97±7.94 | 22.77±6.59 | 8.90±3.03 | 6.94±2.65 | 644.24±230.55 | 571.53±223.78 |
| Language | 832 | 1619 | 68.24±3.94 | 66.48±3.81 | 25.52±6.70 | 20.59±5.62 | 8.76±3.53 | 7.42±2.96 | 618.67±249.45 | 545.05±230.75 |
| Perception | 813 | 1607 | 68.58±3.35 | 66.90±3.21 | 27.67±8.88 | 22.21±6.89 | 8.96±2.98 | 7.20±2.64 | 643±277.83 | 549.47±245.73 |
| Processing speed | 743 | 1431 | 68.36±3.80 | 66.62±4.00 | 25.80±6.87 | 20.66±5.82 | 8.22±3.32 | 6.92±3.02 | 612.23±265.13 | 538.05±244.86 |
| Working memory | 474 | 921 | 68.04±4.60 | 66.34±3.99 | 27.53±5.32 | 22.97±5.90 | 7.99±3.90 | 6.67±3.29 | 574.54±325.65 | 510.02±262.71 |
Motor scores are measured using the MDS-UPDRS part III scale (and previous versions), PD medications are reported in LEDD mg per day and PD duration is reported in mean years.
LEDD, levodopa equivalent daily dose; MDS-UPDRS, Movement Disorder Society - Unified Parkinson’s Disease Rating Scale; PD, Parkinson’s disease; PDnP, PD participants without psychosis; PDP, PD with psychosis.