Number of studies, regression coefficients (or β values), with respective 95% credible intervals (95% CI) are reported here for the nine major cognitive domains for depression and psychosis severity, severity of PD (measured with MDS-UPDRS part III), age, duration of PD, PD medications (expressed in LEDD) and global cognition scores
| Cognitive domains | Depression (beta value, 95% CI) | Psychosis severity (beta value, 95% CI) | UPDRS part III motor symptoms (beta value, 95% CI) | Age (beta value, 95% CI) | PD duration (years) (beta value, 95% CI) | LEDD (beta value, 95% CI) | Global cognition (beta value, 95% CI) |
| Global cognition | −0.08 (−0.16 to −0.01), k=49 | −0.09 (−0.22 to 0.03), k=16 | −0.00 (−0.02 to 0.01), k=79 | −0.04 (−0.06 to −0.02), k=95 | −0.06 (−0.10 to −0.03), k=92 | 0.00 (0.00 to 0.00), k=90 | NA |
| Episodic memory | −0.21 (−0.51 to 0.04), k=14 | NA | 0.00 (−0.04 to 0.04), k=23 | −0.04 (−0.08 to −0.01), k=30 | −0.06 (−0.13 to 0.00), k=28 | 0.00 (0.00 to 0.00), k=25 | 0.00 (−0.01 to 0.02), k=29 |
| Attention | 0.27 (0.01 to 0.55), k=14 | NA | −0.01 (−0.03 to 0.01), k=18 | 0.01 (−0.04 to 0.06), k=23 | 0.02 (−0.08 to 0.11), k=20 | 0.00 (0.00 to 0.00), k=22 | 0.00 (−0.01 to 0.01), k=24 |
| Construction | NA | NA | 0.03 (−0.07 to 0.14), k=9 | −0.08 (−0.16 to −0.02), k=11 | −0.13 (−0.27 to −0.01), k=10 | 0.00 (0.00 to 0.00), k=10 | −0.01 (−0.03 to 0.00), k=11* |
| Executive functions | −0.26 (−0.38 to −0.14), k=16 | NA | −0.01 (−0.02 to 0.02), k=24 | −0.05 (−0.08 to −0.02), k=32 | −0.06 (−0.10 to −0.01), k=28 | 0.00 (0.00 to 0.00), k=29 | 0.00 (−0.01 to 0.01), k=32 |
| Processing speed | −0.25 (−0.35 to −0.14), k=14 | NA | −0.00 (−0.03 to 0.03), k=22 | −0.06 (−0.10 to −0.02), k=28* | −0.05 (−0.11 to 0.00), k=24 | 0.00 (0.00 to 0.00), k=26 | 0.00 (−0.01 to 0.01), k=28 |
| Working memory | −0.06 (−0.23 to 0.16), k=10 | NA | −0.02 (−0.05 to 0.02), k=12 | −0.06 (−0.11 to −0.01), k=15 | −0.07 (−0.13 to −0.01), k=14 | 0.00 (0.00 to 0.00), k=15 | −0.01 (−0.02 to 0.01), k=16 |
| Language | −0.13 (−0.22 to −0.05), k=18 | NA | 0 (−0.02 to 0.03), k=24 | −0.04 (−0.07 to −0.02), k=33 | −0.02 (−0.07 to 0.02), k=29 | 0.00 (0.00 to 0.00), k=30 | 0.00 (−0.01 to 0.00), k=33 |
| Perception | −0.09 (−0.31 to 0.14), k=17 | NA | −0.01 (−0.03 to 0.02), k=26 | −0.08 (−0.12 to −0.04), k=33* | −0.01 (−0.08 to 0.06), k=30 | 0.00 (0.00 to 0.00), k=28 | 0.00 (−0.01 to 0.01), k=27* |
*Divergence of n>100 present in the analysis.
.LEDD, Levodopa equivalent daily dose; MDS-UPDRS, Movement Disorder Society - Unified Parkinson’s Disease Rating Scale; NA, not applicable; PD, Parkinson’s disease.