Characteristics of pre-MS cases
| Pre-MS samples | |||||
| Time from sampling until MS onset | 1–33 years | <5 years | 5–10 years | 10–15 years | 15–33 years |
| N | 669 | 222 | 188 | 147 | 112 |
| Female sex, % | 84 | 87 | 84 | 77 | 86 |
| Median age (IQR) at sampling, years | 25 (21–29) | 26 (22–31) | 25 (20–29) | 25 (21–29) | 22 (19–26) |
| Median age (IQR) at MS onset, years | 33 (28–40) | 29 (25–33) | 32 (27–37) | 37 (32–42) | 43 (38–46) |
| Samples analysed for sNfL | |||||
| Time from sampling until MS onset | 1–32 years | <5 years | 5–10 years | 10–15 years | 15–32 years |
| n | 519 | 112 | 163 | 137 | 107 |
| Female sex, % | 82 | 82 | 85 | 77 | 85 |
| Median age (IQR) at sampling, years | 25 (21–29) | 27 (23–32) | 25 (20–29) | 25 (21–29) | 22 (19–26) |
| Median age (IQR) at MS onset, years | 35 (29–41) | 30 (26–34) | 32 (28–37) | 37 (32–42) | 43 (38–46) |
| Samples analysed for gp350 | |||||
| Time from sampling until MS onset | 1–33 years | <5 years | 5–10 years | 10–15 years | 15–33 years |
| N | 570 | 189 | 159 | 124 | 98 |
| Female sex, % | 84 | 88 | 84 | 77 | 84 |
| Median age (IQR) at sampling, years | 25 (21–29) | 27 (23–31) | 25 (20–29) | 25 (21–28) | 22 (18–26) |
| Median age (IQR) at MS onset, years | 34 (28–40) | 29 (25–33) | 32 (28–37) | 37 (33–42) | 43 (38–46) |
Controls were matched and had the same characteristics. MS onset means clinical MS onset.
MS, multiple sclerosis; sNfL, serum neurofilament light.