Ever head trauma versus never head trauma | |||||
HLA-A*02:01 | Head trauma | Cases/controls | OR (95% CI)* | OR (95% CI)† | AP (95% CI) |
+ | – | 599/1158 | 1.0 (references) | 1.0 (references) | |
+ | + | 253/404 | 1.20 (1.00 to 1.45) | 1.20 (0.99 to 1.46) | |
– | – | 807/996 | 1.58 (1.38 to 1.81) | 1.65 (1.43 to 1.91) | |
– | + | 398/329 | 2.34 (1.96 to 2.80) | 2.39 (1.98 to 2.88) | 0.22 (0.06 to 0.39) |
Head trauma before 5 years prior to index versus never head trauma | |||||
HLA-A*02:01 | Head trauma | Cases/controls | OR (95% CI)* | OR (95% CI)† | AP (95% CI) |
+ | – | 599/1158 | 1.0 (references) | 1.0 (references) | |
+ | + | 218/354 | 1.18 (0.97 to 1.44) | 1.18 (0.96 to 1.46) | |
– | – | 807/996 | 1.58 (1.38 to 1.81) | 1.66 (1.43 to 1.92) | |
– | + | 342/290 | 2.28 (1.89 to 2.75) | 2.29 (1.88 to 2.79) | 0.22 (0.02 to 0.38) |
Head trauma within 5 years prior to index versus never head trauma | |||||
HLA-A*02:01 | Head trauma | Cases/controls | OR (95% CI)* | OR (95% CI)† | AP (95% CI) |
+ | – | 599/1158 | 1.0 (references) | 1.0 (references) | |
+ | + | 35/50 | 1.35 (0.86 to 2.10) | 1.29 (0.81 to 2.06) | |
– | – | 807/996 | 1.58 (1.38 to 1.82) | 1.66 (1.43 to 1.92) | |
– | + | 56/39 | 2.81 (1.84 to 4.43) | 3.23 (2.07 to 5.03) | 0.40 (0.07 to 0.72) |
*Adjusted for age, sex and residential area.
†Adjusted for age, sex, residential area, ancestry, smoking, physical activity, body mass index, HLA-DRB1*15:01, DRB1*03:01, DRB1*13:03, DRB1*08:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01.
AP, attributable proportion; MS, multiple sclerosis.