Table 4

OR with 95% CI of MS among subjects categorised by HLA-A*02:01 status and a reported history of head trauma

Ever head trauma versus never head trauma
HLA-A*02:01Head traumaCases/controlsOR (95% CI)* OR (95% CI) AP (95% CI)
+599/11581.0 (references)1.0 (references)
++253/4041.20 (1.00 to 1.45)1.20 (0.99 to 1.46)
807/9961.58 (1.38 to 1.81)1.65 (1.43 to 1.91)
+398/3292.34 (1.96 to 2.80)2.39 (1.98 to 2.88)0.22 (0.06 to 0.39)
Head trauma before 5 years prior to index versus never head trauma
HLA-A*02:01Head traumaCases/controlsOR (95% CI)* OR (95% CI) AP (95% CI)
+599/11581.0 (references)1.0 (references)
++218/3541.18 (0.97 to 1.44)1.18 (0.96 to 1.46)
807/9961.58 (1.38 to 1.81)1.66 (1.43 to 1.92)
+342/2902.28 (1.89 to 2.75)2.29 (1.88 to 2.79)0.22 (0.02 to 0.38)
Head trauma within 5 years prior to index versus never head trauma
HLA-A*02:01Head traumaCases/controlsOR (95% CI)* OR (95% CI) AP (95% CI)
+599/11581.0 (references)1.0 (references)
++35/501.35 (0.86 to 2.10)1.29 (0.81 to 2.06)
807/9961.58 (1.38 to 1.82)1.66 (1.43 to 1.92)
+56/392.81 (1.84 to 4.43)3.23 (2.07 to 5.03)0.40 (0.07 to 0.72)
  • *Adjusted for age, sex and residential area.

  • †Adjusted for age, sex, residential area, ancestry, smoking, physical activity, body mass index, HLA-DRB1*15:01, DRB1*03:01, DRB1*13:03, DRB1*08:01, B*44:02, B*38:01, B*55:01, DQA1*01:01, DQB1*03:02 and DQB1*03:01.

  • AP, attributable proportion; MS, multiple sclerosis.