Table 3

Changes of clinical parameters at 6-month follow-up in non-motor, motor and levodopa response stratification

Non-Motor Symptom Scale
‘Mild to moderate’‘Severe’‘Very severe’
(≤40)(41–70)(≥71)
nMeanSDP value†nMeanSDP value†nMeanSDP value†P value‡
PDQ-8 Summary Index Change Score527.912.5 <0.001*** 492.716.70.1736013.016.3 <0.001*** 0.003**
Hoehn and Yahr Scale
‘Minimal to mild’‘Moderate’‘Severe’
(≤2.5)(3)(≥4)
nMeanSDP value†nMeanSDP value†nMeanSDP value†P value‡
PDQ-8 Summary Index Change Score937.913.3 <0.001*** 477.619.9 0.010* 1810.916.3 0.006** 0.961
Levodopa challenge test response
‘Low’‘Partial’‘Full’
(<33%)(33%–50%)(>50%)
nMeanSDP value†nMeanSDP value†nMeanSDP value†P value‡
PDQ-8 Summary Index Change Score428.216.0 0.007** 518.016.7 0.001** 668.915.2 <0.001*** 0.993
  • Bold font highlights significant results.

  • *p < 0.05, ** p < 0.01, *** p < 0.001.

  • †Wilcoxon signed-rank tests were used for within-group analyses of change scores between baseline and 6-month follow-up. Multiple comparisons (three strata and seven scales) were corrected with the Benjamini-Hochberg method.

  • ‡Kruskal-Wallis tests were performed for independent samples for between-group analyses of change scores between baseline and 6-month follow-up.

  • PDQ-8, 8-item Parkinson’s Disease Questionnaire.