Number (and percentage) of events and adjusted HRs for miscarriage to the dose during pregnancy, among those with any antiseizure medications treatment in the first trimester
| N events | % | Unadjusted HR | Fully adjusted HR* (95% CI) | |||
| All | Dose | Low | 328 | 14.1 | 1.00 (ref) | 1.00 (ref) |
| Medium | 538 | 14.3 | 1.02 (0.89 to 1.17) | 1.03 (0.90 to 1.17) | ||
| High | 273 | 15.9 | 1.13 (0.96 to 1.32) | 1.12 (0.96 to 1.30) | ||
| Polytherapy or monotherapy | Monotherapy | 987 | 14.6 | 1.00 (ref) | 1.00 (ref) | |
| Polytherapy | 152 | 13.9 | 0.95 (0.80 to 1.12) | 1.01 (0.85 to 1.19) | ||
| Epilepsy | Dose | Low | 133 | 11.1 | 1.00 (ref) | 1.00 (ref) |
| Medium | 327 | 13.4 | 1.23 (1.00 to 1.51) | 1.19 (0.98 to 1.45) | ||
| High | 162 | 15 | 1.37 (1.09 to 1.73) | 1.33 (1.06 to 1.66) | ||
| Polytherapy or monotherapy | Monotherapy | 484 | 12.9 | 1.00 (ref) | 1.00 (ref) | |
| Polytherapy | 138 | 14.3 | 1.12 (0.93 to 1.34) | 1.09 (0.91 to 1.30) | ||
| Bipolar and other psychiatric | Dose | Low | 238 | 15.7 | 1.00 (ref) | 1.00 (ref) |
| Medium | 351 | 15.3 | 0.98 (0.83 to 1.15) | 0.97 (0.83 to 1.13) | ||
| High | 198 | 16.7 | 1.06 (0.88 to 1.27) | 1.04 (0.87 to 1.24) | ||
| Polytherapy or monotherapy | Monotherapy | 695 | 15.8 | 1.00 (ref) | 1.00 (ref) | |
| Polytherapy | 92 | 15.1 | 0.95 (0.77 to 1.17) | 1.01 (0.82 to 1.25) | ||
| Other somatic | Dose | Low | 116 | 16 | 1.00 (ref) | 1.00 (ref) |
| Medium | 153 | 14.6 | 0.92 (0.73 to 1.16) | 0.94 (0.74 to 1.18) | ||
| High | 91 | 16.9 | 1.05 (0.80 to 1.37) | 1.05 (0.81 to 1.37) | ||
| Polytherapy or monotherapy | Monotherapy | 319 | 15.6 | 1.00 (ref) | 1.00 (ref) | |
| Polytherapy | 41 | 15 | 0.94 (0.69 to 1.29) | 1.06 (0.76 to 1.46) |
*Adjusted for: maternal age, year of pregnancy start, Index of Multiple Deprivation, history of pregnancy loss, other indications (epilepsy, bipolar or other psychiatric conditions and other somatic conditions) and consultation rate.