Table 1

Receiver operating characteristic (ROC) curve analysis with areas under the curve (AUC) and optimal cut-offs for separating different gFTD stages and conditions

gFTD conditions	AUC	SE	Optimal cut-off
gFTD conditions	AUC	SE	z-value	Specificity (%)	Sensitivity (%)
Symptomatic carriers versus controls	0.91	0.02	2.83	100	49.5
Converters versus controls	0.89	0.07	3.05	100	42.9
Converters versus presymptomatic carriers	0.86	0.08	3.19	100	42.9
Symptomatic versus presymptomatic carriers	0.88	0.02	3.20	100	46.2
Presymptomatic carriers versus controls	0.57	0.03
Symptomatic carriers versus converters	0.59	0.10

Data from lab 1; optimal cut-off values are given as z-values (corrected for age). For the data from lab 2 and 3, see figure 1B and C.
gFTD, genetic frontotemporal dementia.