Factors associated with a change in intraventricular haemorrhage volume
| Model/variable | β (95% CI) | P value* |
| Unadjusted analysis | ||
| MIS+alteplase | −1.20 (−2.16 to −0.25) | 0.01 |
| Multivariable analysis | ||
| MIS+alteplase | −0.80 (−1.37 to −0.22) | 0.007 |
| Age (years) | 0.02 (0.003 to 0.04) | 0.09 |
| Male sex | 0.29 (−0.27 to 0.85) | 0.31 |
| Black race† | 0.09 (−0.64 to 0.83) | 0.80 |
| Hispanic ethnicity | 0.40 (−0.34 to 1.15) | 0.29 |
| Diabetes | 0.19 (−0.39 to 0.77) | 0.52 |
| GCS at randomisation | 0.14 (0.03 to 0.26) | 0.02 |
| ICH volume, stability | 0.03 (0.01 to 0.05) | <0.001 |
| IVH volume, stability | −0.53 (−0.57 to −0.48) | <0.001 |
| Ictus to EOT time (hours) | −0.01 (−0.02 to −0.0004) | 0.06 |
| Baseline WBC | 0.15 (0.11 to 0.19) | <0.001 |
| EVD placement | 0.22 (−0.55 to 0.99) | 0.57 |
*P<0.05 was considered statistically significant.
†Black race was considered separately because black patients had higher ICH severity and poor outcomes.
EOT, end of treatment; EVD, external ventricular drainage; GCS, Glasgow Coma Scale; ICH, intracerebral haemorrhage; IVH, intraventricular haemorrhage; MIS, minimally invasive surgery; WBC, white blood cell.