Summary of VTE in ALS literature
| Authors | DOI/access | Year | Study description | Follow-up (years) | No of patients | % death by PE | % unidentified sudden death | Incidence of VTE |
| Barnabe et al 20 | 10.1016/j.rpth.2023.102287 | 2023 | Prospective cohort study of 227 patients at a French hospital with a median follow-up of 717 days. | 2 | 227 | 0 | 0 | 2.93% annual |
| Takeda et al 9 | 10.1016/j.jns.2024.122896 | 2023 | Prospective cohort study investigating the incidence of incidental DVT in 65 patients with ALS. | n/a | 65 | N/A | N/A | 2% incidental DVT annual |
| Kupelian et al 23 | 10.1212/CPJ.0000000000200110 | 2023 | Retrospective observational study over 10 years comparing the number of VTE-related claims in 4205 patients with ALS and 21 025 controls using a US health insurance claims database. | 10 | 4205 | N/A | N/A | 1.99% annual |
| Caballero-Eraso et al 19 | 10.1016/j.thromres.2022.01.002 | 2022 | Prospective cohort study following 44 patients for 2 years | 2 | 44 | N/A | N/A | 8.5% annual |
| Mira Padilla et al 15 | 10.1183/13993003.congress-2021.PA3584 | 2021 | Retrospective observational study with 218 patients with ALS in Spain | 10 | 218 | 1 | N/A | 3.9% in 10 years |
| Forrest et al 16 | 10.3109/21678421.2014.984724 | 2015 | Audit of 130 patients with ALS followed up over 12 months in an Australian clinic | 1 | 130 | 0 | N/A | 3.75% annual (for PE) |
| Gladman et al 3 | 10.1212/WNL.0000000000000405 | 2014 | Prospective study of 50 patients in a Canadian clinic followed up for clinically important VTE for 1 year | 1 | 50 | 0 | 0 | 11.2% annual incidence (36% and 36% for leg-onset or leg weakness) |
| Gil et al 14 | 10.1111/j.1468–1331.2008.02307.x | 2008 | Prospective follow-up study of 302 patients with ALS in France investigating cause of death via patient records and attending physicians | 1 | 302 | 2 | 0.7 | N/A |
| Corcia et al 1 | 10.1080/17482960701656940 | 2008 | Postmortem study on cohort of 100 patients with ALS in France investigating cause of death | N/A | 100 | 6 | N/A | N/A |
| Qureshi et al 18 | 10.1212/01.wnl.0000250444.30622.ee | 2007 | DVT in patients with ALS in 2 clinical trials in the USA | N/A | 501 | N/A | N/A | 2.7% annual (for DVT) |
| Elman et al 17 | 10.1080/14660820510043226 | 2005 | Audit of 438 patients with ALS over 4 years | 4 | 438 | N/A | N/A | 3.3% annual (for VTE) |
ALS, amyotrophic lateral sclerosis; DVT, deep vein thrombosis; N/A, not available; VTE, venous thromboembolism.