Regular ArticleDopa-Induced Blood Flow Responses in Nonhuman Primates
References (45)
- et al.
Simple and rapid micromethod for the determination of levodopa and 3-O-methyldopa in human plasma by high-performance liquid chromotography with coulometric detection
J. Chromatogr.
(1986) - et al.
Dopaminergic innervation of the cerebral cortex: Unexpected differences between rodents and primates
Trends Neurosci.
(1991) - et al.
Apomorphine increases glucose utilization in the substantia nigra, subthalamic nucleus and corpus striatum of rat
Brain Res.
(1978) - et al.
Functional MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys
Exp. Neurol.
(1999) - et al.
N-Methyl--aspartate receptor blockade differentially modifies regional cerebral metabolic responses to D1 and D2 dopamine agonists in rats with a unilateral 6-hydroxydopamine lesion
Neuroscience
(1993) - et al.
Detecting activations in PET and fMRI: Levels of inference and power
NeuroImage
(1996) - et al.
Levodopa-induced local cerebral blood flow changes in Parkinson's disease and related disorders
J. Neurol. Sci.
(1995) - et al.
The dose–response relationship for memory impairment by anticholinergic drugs
Comprehensive Psychiatry
(1989) - et al.
Regional cerebral blood flow in Parkinsonism
J. Neurol. Sci.
(1978) - et al.
Simultaneous determination of levodopa methylester, levodopa, 3-O-methyldopa and dopamine in plasma by high-performance liquid chromotography with electrochemical detection
J. Chromatogr.
(1994)
The effects of -DOPA on regional cerebral glucose utilization in rats with unilateral lesions of the substantia nigra
Brain Res.
Cerebral pharmacodynamics of anaesthetic and subanaesthetic doses of ketamine in the normoventilated pig
Acta Anaesthesiol. Scand.
Pharmacokinetics and related pharmacodynamics of anticholinergic drugs
Acta Anaesthesiol. Scand.
PET measurement of dopamine D2 receptor-mediated changes in striatopallidal function
J. Neurosci.
Baboon basal ganglia stereotaxy using internal MRI landmarks: Validation and application to PET imaging
J. Comput. Assisted Tomogr.
An in vivo test of striatopallidal sensitivity to a specific D2 agonist
Mov. Disord.
A metric for testing the accuracy of cross-modality image registration: Validation and application
J. Comput. Assisted Tomogr.
In vivo regional cerebral blood flow responses to a dopamine D1 agonist
J. Neuropsychiatry Clin. Neurosci.
Noninvasive functional brain mapping by change-distribution analysis of averaged PET images of H152O tissue activity
J. Nucl. Med.
The effect of the dopamine agonist, apomorphine, on regional cerebral blood flow in normal volunteers
Psychol. Med.
The effects of chloral hydrate anaesthesia on the metabolic response in the substantia nigra to apomorphine
Brain Res.
Cited by (32)
Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease
2019, CortexCitation Excerpt :Both levodopa and DAA augment dopaminergic tone in PD and both appear to increase rCBF in areas associated with PD symptoms, despite the differing mechanisms of action. Pharmacological neuroimaging studies in non-human primates with levodopa (Hershey, Black, Carl, & Perlmutter, 2000) and non-ergot DAAs (Black, Gado, & Perlmutter, 1997; Black et al., 2002, 2011) indicate that different dopaminergic agents have unique rCBF responses, suggesting that rCBF changes are mediated by the action as a dopamine precursor (levodopa) or receptor agonist (DAA). Moreover, studies in healthy volunteers investigating the relationship between CBF and activity changes in specific neurotransmitter systems (Donahue et al., 2014; Dukart et al., 2018) showed that CBF reflects specific metabolic demands from diverse underlying neurotransmitter systems, supporting the notion that different pharmacological agents provide unique patters of CBF changes associated to receptor availability, affinity and function.
Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease
2018, Neurobiology of AgingCitation Excerpt :More work is also needed to clarify whether levodopa's impact on response inhibition is purely due to changes in dopaminergic signaling because levodopa is also a precursor for norepinephrine, which plays a role in response inhibition (Bari et al., 2009; Rae et al., 2016). In addition, while previous studies have concluded that carbidopa-levodopa does not significantly alter cerebral blood flow (Henriksen and Boas, 1985; Hershey et al., 2000, 2003), future studies could include arterial spin labeling sequences to control for any subtle blood flow differences based on medication use. Another potential issue relates to the sample size of the fMRI cohort, which limited our ability to examine PD subgroups, for example, rigid versus tremor dominant, or left- versus right-lateralized symptom groups.
Dopamine-induced dissociation of BOLD and neural activity in macaque visual cortex
2014, Current BiologyCitation Excerpt :Anesthetized animals also allow us to discriminate small changes because the anesthetized model allows for longer averaging times and higher SNR. However, differences in regional CBF under DAergic influence have been observed between awake and anesthetized animals [42], and differences may depend on the type of anesthesia. Because neuromodulatory properties strongly depend on the animal’s behavioral state, including its level of alertness, this highlights the complexity of fMRI studies of neuromodulation, and it would be ideal to have a comparison of dopaminergic effects in awake and anesthetized animals.
Postprandial plasma PYY concentrations are associated with increased regional gray matter volume and rCBF declines in caudate nuclei - A combined MRI and H <inf>2</inf><sup>15</sup>O PET study
2012, NeuroImageCitation Excerpt :This finding was interpreted as a switch in dopamine receptor subtype stimulation (D2/D3 vs. D1/D5) associated with dose escalation (Ren et al., 2009) and indicates that different effects on brain structure and function may be seen in pharmacologic versus physiologic situations. L-DOPA, the direct precursor of dopamine, increased striatal rCBF in awake and but decreased rCBF in anesthesized healthy, nonhuman primates (Hershey et al., 2000). In awake humans, L-DOPA increased striatal rCBF (i.e. bilateral putamen) (Hershey et al., 1998).
Improvements in both psychosis and motor signs in Parkinson's disease, and changes in regional cerebral blood flow after electroconvulsive therapy
2011, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :To our knowledge, this is a new finding about the effects of ECT on rCBF in PD patients. Although it has been reported that levodopa significantly increased rCBF in the right temporal cortex and bilateral frontal cortex in nonhuman primates (Hershey et al., 2000), the dosage of levodopa during the study period was fixed in the present study. Therefore, our finding may have been caused by ECT.
Intravenous levodopa administration in humans based on a two-compartment kinetic model
2007, Journal of Neuroscience Methods