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Brain Energy Metabolism, Cognitive Function and Down-regulated Oxidative Phosphorylation in Alzheimer Disease

https://doi.org/10.1006/neur.1996.0065Get rights and content

Abstract

Reduced brain glucose utilization in early stages of Alzheimer disease, as measured within vivopositron emission tomography, reflects potentially reversible down-regulation of gene expression for oxidative phosphorylation within neuronal mitochondria. Such down-regulation may occur when neuronal energy demand is first reduced by synaptic dysfunction or loss.

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