Elsevier

NeuroImage

Volume 7, Issue 1, January 1998, Pages 30-40
NeuroImage

Regular Article
Event-Related fMRI: Characterizing Differential Responses

https://doi.org/10.1006/nimg.1997.0306Get rights and content

Abstract

We present an approach to characterizing the differences among event-related hemodynamic responses in functional magnetic resonance imaging that are evoked by different sorts of stimuli. This approach is predicated on a linear convolution model and standard inferential statistics as employed by statistical parametric mapping. In particular we model evoked responses, and their differences, in terms of basis functions of the peri-stimulus time. This facilitates a characterization of the temporal response profiles that has a high effective temporal resolution relative to the repetition time. To demonstrate the technique we examined differential responses to visually presented words that had been seen prior to scanning or that were novel. The form of these differences involved both the magnitude and the latency of the response components. In this paper we focus on bilateral ventrolateral prefrontal responses that show deactivations for previously seen words and activations for novel words.

References (17)

  • K.J. Friston et al.

    Analysis of fMRI time-series revisited

    NeuroImage

    (1995)
  • K.J. Friston et al.

    Characterising evoked hemodynamics with fMRI

    NeuroImage

    (1995)
  • K.J. Worsley et al.

    Analysis of fMRI time-series revisited—again

    NeuroImage

    (1995)
  • E.A. DeYoe et al.

    Time course of event-related MR: Signal enhancement in visual and motor cortex

    Proc. Soc. Mag. Res. Med.

    (1992)
  • G. Boynton et al.

    Linear systems analysis of functional magnetic resonance imaging in human V1

    J. Neurosci.

    (1996)
  • R. Buckner et al.

    Detection of transient and distributed cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging

    Proc. Natl. Acad. Sci. USA

    (1996)
  • K.J. Friston et al.

    Analysis of functional MRI time series

    Hum. Brain Mapping

    (1994)
  • K.J. Friston et al.

    Spatial registration and normalisation of images

    Hum. Brain Mapping

    (1995)
There are more references available in the full text version of this article.

Cited by (0)

M. D. RuggM. G. H. Coles

View full text