Elsevier

NeuroImage

Volume 14, Issue 5, November 2001, Pages 1097-1104
NeuroImage

Regular Article
Comparison of Spike-Triggered Functional MRI BOLD Activation and EEG Dipole Model Localization

https://doi.org/10.1006/nimg.2001.0896Get rights and content

Abstract

We studied six patients with localization-related epilepsy, frequent interictal epileptiform discharges, and positive spike-triggered blood oxygen level-dependent functional MRI (BOLD-fMRI) findings. EEG source analysis solutions based on 64-channel EEG recorded in a separate session outside the scanner were obtained using dipole models and compared to the BOLD localization. The BOLD and structural images were coregistered, allowing the measurement of distances between the generator models and BOLD activation(s) and structural lesion when present. In all cases dipole models could be found that explained a sufficient amount of the data and that were anatomically concordant with the BOLD localization. In the five cases with structural abnormality visible on T1 scans, the BOLD activation overlapped or was in close proximity to the abnormaility. The overall mean distance between the main moving dipole and the center of the nearest BOLD activation was 3.5 and 2.2 cm for the negative and positive peaks, respectively, including one case of a deep BOLD activation, in which the distance was 5 cm. In conclusion, the degree of agreement between the BOLD and EEG source localization indicates that the combination of these two noninvasive techniques offers the possibility of advancing the study of the generators of epileptiform electrical activity.

References (41)

  • G. Alarcon et al.

    Intracerebral propagation of interictal activity in partial epilepsy: Implications for source localisation

    J. Neurol. Neurosurg. Psych.

    (1994)
  • J.A. Ashburner et al.

    Nonlinear spatial normalization using basis functions

    NeuroImage

    (1999)
  • G. Bonmassar et al.

    Visual evoked potential (VEP) measured by simultaneous 64-channel EEG and 3T fMRI

    NeuroReport

    (1999)
  • D. Cohen et al.

    MEG versus EEG localization test using implanted sources in the human brain

    Ann. Neurol.

    (1990)
  • E.A. Disbrow et al.

    Functional MRI at 1.5 tesla: A comparison of the blood oxygenation level-dependent signal and electrophysiology

    Proc. Nat. Acad. Sci. USA

    (2000)
  • J.S. Ebersole et al.

    Spike voltage topography identifies two types of fronto-temporal epileptic foci

    Neurology

    (1991)
  • J.S. Ebersole

    EEG and MEG dipole source modeling

  • K.J. Friston et al.

    Spatial registration and normalization of images

    Hum. Brain Mapp.

    (1995)
  • K.J. Friston et al.

    Statistical parametric maps in functional imaging: A general linear approach

    Hum. Brain Mapp.

    (1995)
  • M. Fuchs et al.

    Linear and nonlinear current density reconstructions

    J. Clin. Neurophysiol.

    (1999)
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