Summary
This autopsy case report describes a clinically aggressive, histologically well-differentiated, diffuse, primary leptomeningeal astrocytoma. This rare tumour produced a meningitic clinical picture associated with hydrocephalus, focal spinal cord necrosis, and signs of spinal and cranial nerve root irritation. Despite the microscopic features, death occurred approximately 7 weeks after the first meningeal symptoms.
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References
Abbott KH, Glass B (1955) Intracranial extracerebral (leptomeningeal) glioma. Proceedings of the 2nd International Congress on Neuropathol, Section VII, Excerpta Medica, Amsterdam, p 786
Bailey OT (1936) Relation of glioma of the leptomeninges to neuroglia nests. Arch Pathol 21:584–600
Bailey P, Robitaille Y (1985) Primary diffuse leptomeningeal gliomatosis. Can J Neurol Sci 12:278–281
Blumenkopf B, Gutierrez J, Bennett W (1986) Primary leptomeningeal gliomatosis and “numb, clumsy hands”: a case report. Neurosurgery 18:363–366
Case Records of the Massachusetts General Hospital (1978) Weekly clinicopathological exercises. N Engl J Med 299: 1060–1067
Choucair AK, Levin VA, Gutin PH, Davis RL, Silver P, Edwards MSB, Wilson CB (1986) Development of multiple lesions during radiation therapy and chemotherapy in patients with gliomas. J Neurosurg 65:654–658
Cohen AR, Wisoff JH, Allen JC, Epstein F (1989) Malignant astrocytomas of the spinal cord. J Neurosurg 70:50–54
Cooper IS, Kernohan JW (1951) Heterotopic glial nests in the subarachnoid space: histopathologic characteristics, mode of origin and relation to meningeal gliomas. J Neuropathol Exp Neurol 10:16–29
Cooper IS, Craig WM, Kernohan JW (1951) Tumors of the spinal cord: primary extramedullary gliomas. Surg Gynecol Obstet 92:183–190
Daum S, Le Beau, Billet R (1963) Gliomas sus-tentoriels a development extra-cérébral. Neurochirugie 9:279–288
Feldmann E, Bromfield E, Navia B, Pasternak GW, Posner JB (1986) Hydrocephalic dementia and spinal cord tumor. Report of a case and review of the literature. Arch Neurol 43:714–718
Friede RL, Pollak A (1978) The cytogenetic basic for classifying ependymomas. J Neuropathol Exp Neurol 37:103–118
Ho K-L, Hoschner JA, Wolfe DE (1981) Primary leptomeningeal gliomatosis: symptoms suggestive of meningitis. Arch Neurol 38:662–666
Horoupian DS, Lax F, Suzuki K (1979) Extracerebral leptomeningeal astrocytoma mimicking a meningioma. Arch Pathol Lab Med 103:676–679
Kalyan-Raman UP, Cancilla PA, Case MJ (1983) Solitary, primary malignant astrocytoma of the spinal leptomeninges. J Neuropathol Exp Neurol 42:517–521
Kernohan JW, Woltman HW, Adson AW (1931) Intramedullary tumours of the spinal cord: a review of fifty-one cases, with an attempt at histologic classification. Arch Neurol Psychiatry 25:679–701
Kitihara M, Katakura R, Wada T, Namiki T, Suzuki J (1985) Diffuse form of primary leptomeningeal gliomatosis. Case report. J Neurosurg 63:283–287
Korein J, Feigin I, Shapiro MF (1957) Oligodendrogliomatosis with intracranial hypertension. Neurology 7:589–594
Packer RJ, Allen J, Nielsen S, Petito C, Deck M, Jereb B (1983) Brain stem glioma: clinical manifestations of meningeal gliomatosis. Ann Neurol 14:177–182
Sceats DJ, Quisling R, Rhoton AL, Ballinger WE, Ryan P (1986) Primary leptomeningeal glioma mimicking an acoustic neuroma: case report with review of the literature. Neurosurgery 19:649–654
Shungshoit S, Kasantikul V, Suwanwela N, Suwanwela C (1984) Solitary primary intracranial extracerebral glioma. Case report. J Neurosurg 61:777–781
Sumi SM, Leffman H (1968) Primary intracranial leptomeningeal glioma with persistent hypoglycorrhachia. J Neurol Neurosurg Psychiatry 31:190–194
Thompson T (1929) The diagnosis of leptomeningcoma of the spinal cord: with a report of three cases successfully treated. Lancet I:325–330
Wilkinson HA, Mark VH (1968) Thoracic extramedullary astrocytoma: case report. Neurosurgery 28:504–508
Woltman HW, Kernohan JW, Adson AW, Winchell MC (1950) Intramedullary tumours of spinal cord and gliomas of intradural portion of filum terminale. Arch Neurol Psychiatry 65:378–395
Yung WA, Horten BC, Shapiro WR (1980) Meningeal gliomatosis: a review of 12 cases. Ann Neurol 8:605–608
Zentner J, Anagnostopoulos J, Gilsbach J (1988) Solitary intracranial extracerebral glioma. Neurochirurgia (Stuttg) 31:101–103
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This case was Diagnostic Case 15 of the 29th (1989) Annual Meeting of the Canadian Association of Neuropathologists
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Ramsay, D.A., Goshko, V. & Nag, S. Primary spinal leptomeningeal astrocytoma. Acta Neuropathol 80, 338–341 (1990). https://doi.org/10.1007/BF00294654
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DOI: https://doi.org/10.1007/BF00294654