Summary
Central neurocytoma has been characterised by its intraventricular localisation, predominant occurrence in young adults, oligodendroglioma-like histology, benign course and ultrastructural evidence for neuronal differentiation. Eleven intraventricular central neurocytomas were studied histopathologically, employing cell type-specific immunocytochemical markers and electron microscopic analysis. In the past, these lesions have caused diagnostic problems since central neurocytomas share basic histopathological features with other periventricular neoplasms. Accordingly, several tumours of this series had previously been classified as ependymomas of the foramen of Monro or oligodendrogliomas. Although generally regarded as benign lesions, two central neurocytomas of this series showed histopathological evidence of anaplasia, with focal necrosis, mitotic activity and vascular proliferation. All central neurocytomas exhibited immunoreactivity for neuronspecific enolase and synaptophysin, indicating consistent neuronal differentiation. Three tumours were studied by electron microscopy and contained synaptic vesicles, neuritic processes and neurosecretory granules. In addition, one tumour contained ganglioid cells and this was associated with focal immunoreactivity for neurofilament protein, suggesting that some central neurocytomas may, at least focally, continue to differentiate towards the formation of mature neurons. Two of the tumours expressed glial fibrillary acidic protein in a considerable percentage of neoplastic cells which demonstrates a capacity for bipotential, i.e. glial and neuronal differentiation. We conclude that the central neurocytoma can be reliably diagnosed using antibodies to neuron-specific enolase and synaptophysin, and that histogenetically, this neoplasm is derived from a neuroectodermal precursor cell capable of both, neuronal and glial differentiation. The hypothesis is proposed that the central neurocytoma originates from the subependymal plate of the lateral ventricles, an embryonal matrix cell layer which postnatally maintains a limited proliferative potential.
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Aguzzi A, Wiestler OD, Kleihues P (1988) Differenzierung im Medulloblastom: Immunhistochemische Untersuchung an 247 Fällen der Therapiestudie SIOP/GPO MED 84. Verh Dtsch Ges Pathol 72:284–287
Alvarez-Buylla A, Nottebohm F (1988) Migration of young neurons in adult avian brain. Nature 335:353–354
Bayer SA (1983) [3H]Thymidine-radiographic studies of neurogenesis in the rat olfactory bulb. Exp Brain Res 50:329–340
Bennett JP, Rubinstein LJ (1984) The biological behaviour of primary cerebral neuroblastoma: a reappraisal of the clinical course in a series of 70 cases. Ann Neurol 16:21–27
Burger PC, Grahmann FC, Bliestle A, Kleihues P (1987) Differentiation in the medulloblastoma. A histological and immunohistochemical study. Acta Neuropathol (Berl) 73:115–123
Copeland DD, Bigner DD (1977) The role of the subependymal plate in avian sarcoma virus brain tumor induction: comparison of incipient tumors in neonatal and adult rats. Acta Neuropathol (Berl) 38:1–6
Hassoun J, Gambarelli D, Grisoli F, Pellet W, Salamon G, Pellisier JF, Toga M (1982) Central neurocytoma. Acta Neuropathol (Berl) 56:151–156
Hopewell JW (1975) The subependymal plate and the genesis of gliomas. J Pathol 117:101–103
Horten BC, Rubinstein LJ (1976) Primary cerebral neuroblastoma. A clinicopathological study of 35 cases. Brain 99:735–756
Jerdan MS, White III CL, Solomon D, Scheithauer BW, Clark AW (1983) Differentiated cerebral neuroblastoma in adults. J Neuropathol Exp Neurol 42:305
Kleihues P, Lantos PL, Magee PN (1976) Chemical carcinogenesis in the nervous system. Int Rev Exp Pathol 15:153–232
Lantos PL (1977) The role of the subependymal plate in the origin of gliomas induced by ethylnitrosourea in rat brain. Experientia 99:571–577
Mannoji H, Takeshita I, Fukui M, Ohta M, Kitamura K (1981) Glial fibrillary acidic protein in medulloblastoma. Acta Neuropathol (Berl) 55:63–69
Nishio S, Tashima T, Takeshita I, Fukui M (1988) Intraventricular neurocytoma: clinicopathological features of six cases. J Neurosurg 68:665–670
Ojeda VJ, Stokes BAR, Lee MA, Thomas GW, Papadimitiuo JM, Cala LA, Stevens SMB, O'Neill P (1986) Primary cerebral neuroblastomas. A clinicopathological study of one adolescent and five adult patients. Pathology 18:41–49
Pearl GS, Takei Y, Bakay RA, Davis P (1985) Intraventricular primary cerebral neuroblastoma in adults: a report of three cases. Neurosurgery 16:847–849
Rorke LB (1983) The cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropathol Exp Neurol 42:1–15
Rorke LB (1985) Classification and grading of childhood brain tumors. Overview and statement of the problem. Cancer 56:1848–1849
Rubinstein LJ (1985) Embryonal central neuroepithelial tumors and their differentiating potential. A cytogenetic view of a complex neuro-oncological problem. J Neurosurg 62:795–805
Schwechheimer K, Wiedenmann B, Franke KK (1987) Synaptophysin: a reliable marker for medulloblastomas. Virchows Arch [A] 411:53–59
Townsend JJ, Seaman JP (1986) Central neurocytoma — a rare benign intraventricular tumor. Acta Neuropathol (Berl) 71:167–170
Vick A, Lin Mei-Jane, Bigner DD (1977) The role of the subependymal plate in glial tumorigenesis. Acta Neuropathol (Berl) 40:63–71
Wilson AJ, Leaffer DH, Kohout ND (1985) Differentiated cerebral neuroblastoma: a tumor in need of discovery. Hum Pathol 16:647–649
Zülch KJ (1986) Brain tumors: their biology and pathology, 3rd edn. Springer, Berlin Heidelberg New York Tokyo, pp 261–267
Zülch KJ, Schmid EE (1955) Über das Ependymom der Seitenkammern am Foramen Monroi. Arch Psychiatr Nervenkr 193:214–228
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von Deimling, A., Janzer, R., Kleihues, P. et al. Patterns of differentiation in central neurocytoma. Acta Neuropathol 79, 473–479 (1990). https://doi.org/10.1007/BF00296105
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DOI: https://doi.org/10.1007/BF00296105