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Sensory peripheral neuropathy of vitamin B12 deficiency: A primary demyelinating disease?

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Summary

In five patients with peripheral neuropathy due to vitamin B12 deficiency, electrodiagnostic studies demonstrated severe reduction in sensory nerve conduction velocities compatible with a demyelinating disorder affecting sensory nerve fibres. It is suggested that in some patients lack of vitamin B12 may cause primary sensory demyelinating neuropathy.

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References

  1. Agamanolis DP, Chester EM, Victor M, Kark JA, Hines JD, Harris JW (1976) Neuropathology of experimental vitamin B12 deficiency in monkeys. Neurology 26:905–914

    Google Scholar 

  2. Agamanolis DP, Victor M, Harris JW, Hines JD, Chester EM (1978) An ultrastructural study of subacute combined degeneration of the spinal cord in vitamin B12 deficient rhesus monkeys. J Neuropathol Exp Neurol 37:273–299

    Google Scholar 

  3. Bannerji NK, Hurwitz LJ (1971) Nervous system manifestations after gastric surgery. Acta Neurol Scand 47:485–513

    Google Scholar 

  4. Chanarin I, Deacon R, Perry J, Lumb M (1981) Annotation. How vitamin B12 acts. Br J Haematol 47:487–491

    Google Scholar 

  5. Frenkel EP (1973) Abnormal fatty acid metabolism in peripheral nerves of patients with pernicious anemia. J Clin Invest 52:1237–1245

    Google Scholar 

  6. Kimura J (1983) Electrodiagnosis in disease of nerve and muscle. Principle and practice. Davis, Philadelphia

    Google Scholar 

  7. Pant SS, Asbury AK, Richardson EP (1983) The myelopathy of pernicious anemia. A neuropathological reappraisal. Acta Neurol Scand [Suppl 1] 44:1–36

    Google Scholar 

  8. Schaumburg HH, Spencer PS, Thomas PK (1983) Disorders of peripheral nerves. Davis, Philadelphia, pp 64–66

    Google Scholar 

  9. Small DH, Carnegie PR (1981) Myelopathy associated with vitamin B12 deficiency. New approach to an old problem. TINS 4:10–11

    Google Scholar 

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Steiner, I., Kidron, D., Soffer, D. et al. Sensory peripheral neuropathy of vitamin B12 deficiency: A primary demyelinating disease?. J Neurol 235, 163–164 (1988). https://doi.org/10.1007/BF00314308

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  • DOI: https://doi.org/10.1007/BF00314308

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