Skip to main content
Log in

Periventricular hyperintensity on magnetic resonance imaging correlated with brain ageing and atrophy

  • Diagnostic Neuroradiology
  • Published:
Neuroradiology Aims and scope Submit manuscript

Summary

Fifty-two patients with cerebrovascular risk factors without neurological abnormalities were reviewed with respect to periventricular hyperintensity (PVH) on T2-weighted magnetic resonance imaging (MRI); brain atrophy was also assessed by CT and T1-weighted MRI. Extensive PVH showed a stronger correlation with agerelated atrophy than mild or absent PVH. The relative volume of brain affected by PVH, calculated by computer, also correlated with brain atrophy, especially ventricular enlargement. The effects of PVH on brain ageing and atrophy is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Referneces

  1. Awad IA, Spetzler RF, Hodak JA, Awad CA, Williams F Jr (1982) Incidental lesions noted on magnetic resonance imaging of the brain: prevalence and clinical significance in various age groups. Neurosurgery 20: 222–227

    Google Scholar 

  2. Bradley WG, Waluch V, Brant-Zawadzki M, Vadley RA, Wycoff RR (1984) Patchy, periventricular white matter lesions in the elderly: a common observation during NMR imaging. Noninvas Med Imaging 1: 35–41

    Google Scholar 

  3. Brant-Zawadzki M, Fein G, Van Dyke C, Van Dyke C, Kiernan R, Davenport L, DeGroot J (1985) MR imaging of the aging brain: patchy white matter lesions and dementia. AJNR 6: 675–682

    Google Scholar 

  4. George AE, Leon MJ de, Gentes CI, Miller J, London E, Budzilovich GN, Ferris S, Chase N (1986) Leukoencephalopathy in normal and pathologic aging. 1. CT of brain lucencies. AJNR 7: 561–566

    Google Scholar 

  5. George AE, Leon MJ de, Kalnin A, Rosner L, Goodgold A, Chase N (1986) Leuko-encephalopathy in normal and pathologic aging. 2. MRI of brain lucencies. AJNR 7: 567–570

    Google Scholar 

  6. Gerard G, Weisberg LA (1986) MRI periventricular lesions in adults. Neurology 36: 998–1000

    Google Scholar 

  7. Sarpel G, Chaudry F, Hindo W (1987) Magnetic resonance imaging of periventricular hyperintensity in a veterans administration hospital population. Arch Neurol 44: 725–728

    Google Scholar 

  8. Zimmerman RD, Fleming CA, Lee BCP, St-Louis LA, Deck MDF (1986) Periventricular hyperintensity as seen by magnetic resonance: prevalence and significance. AJR 146:443–450

    Google Scholar 

  9. Kertesz A, Black SE, Tokar G, Benbe T, Can T, Nicholson L (1988) Periventricular and subcortical hyperintensities on magnetic resonance imaging. Arch Neurol 45: 404–405

    Google Scholar 

  10. Wilson DA, Steiner RE (1986) Periventricular leukomalacia: evaluation with MR imaging. Radiology 160: 507–511

    Google Scholar 

  11. Hachinski VC, Potter P, Mersky H (1987) Leukoaraiosis. Arch Neurol 44: 24–29

    Google Scholar 

  12. Awad IA, Modic M, Little JR, Furlan AJ, Weinstein M (1986) Focal parenchymal lesions in transient ischemic attacks: correlation of computed tomography and magnetic resonance imaging. Stroke 17:399–403

    Google Scholar 

  13. Rothrock JF, Lyden PD, Hesselink JJ, Brown JJ, Healy ME (1987) Brain magnetic resonance imaging in the evaluation of lacunar stroke. Stroke 18:781–786

    Google Scholar 

  14. Awad IA, Spetzler RF, Hodak JA, Awad CA, Carey R (1986) Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors. Stroke 17: 1084–1089

    Google Scholar 

  15. Lechner H, Schmidt R, Bertha G, Justich E, Offenbacher H (1988) Nuclear magnetic resonance imaging white matter lesions and risk factors for stroke in normal individuals. Stroke 19:263–265

    Google Scholar 

  16. Cala LA, Thickbroom GW, Black JL, Collins DWK, Mastaglia FL (1981) Brain density and cerebrospinal fluid space size: CT of normal volunteers. AJNR 2: 41–47

    Google Scholar 

  17. Yamaura H, Ito M, Kubota K, Matsuzawa T (1980) Brain atrophy during aging: a quantitative study with computed tomography. J Gerontol 35: 492–498

    Google Scholar 

  18. Takeda S, Matsuzawa T (1984) Brain atrophy during aging: a quantitative study using computed tomography. J Am Geriatr Soc 32: 520–524

    Google Scholar 

  19. Takeda S, Matsuzawa T, Matsui H (1988) Age-related changes in regional cerebral blood flow and brain volume in healthy subjects. J Am Geriatr Soc 36:293–297

    Google Scholar 

  20. Meguro K, Hatazawa J, Yamaguchi T, Itoh M, Matsuzawa T, Ono S, Miyazawa H, Hishinuma T, Yanai K, Sekita Y, Yamada K (1990) Cerebral circulation and oxygen metabolism associated with subclinical periventricular hyperintensity as shown by magnetic resonance imaging. Ann Neurol 28: 378–383

    Google Scholar 

  21. Yamada K, Matsuzawa T, Ono S, et al (1987) Age-related changes in volumes of the ventricles, sulci and periventricular hyperintensity area: a quantitative study using magnetic resonance imaging. Jpn J Geriatr 23: 575–579

    Google Scholar 

  22. Awad IA, Spetzler RF, Hodak JA (1986) Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Post-mortem pathological correlations. Stroke 17: 1090–1097

    Google Scholar 

  23. Bowsher D (1957) Pathway of absorption from the cerebrospinal fluid. An autoradiographic study in the cat. Anat Res 128: 23–39

    Google Scholar 

  24. Cserr HF, Cooper DN, Milhorat TH (1977) Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from caudate nucleus. Exp Eye Res 25 [Suppl]: 461–473

    Google Scholar 

  25. Rowe JW, Kahn RL (1987) Human aging: usual and successful. Science 237: 143–149

    Google Scholar 

  26. Drayer BF (1988) Imaging of the aging brain. I. Normal findings. Radiology 166: 785–796

    Google Scholar 

  27. Drayer BP (1988) Imaging of the aging brain. II. Pathologic conditions. Radiology 166: 797–806

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Meguro, K., Yamaguchi, T., Hishinuma, T. et al. Periventricular hyperintensity on magnetic resonance imaging correlated with brain ageing and atrophy. Neuroradiology 35, 125–129 (1993). https://doi.org/10.1007/BF00593968

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00593968

Key words

Navigation