Summary
L-dopa 7 µg·kg−1·min−1 was given intravenously over 2 h to six healthy subjects, controlled by an infusion of saline on a separate occasion, with measurement of plasma renin activity (PRA), urinary sodium and potassium excretion, effective renal plasma flow (ERPF), glomerular filtration rate (GFR), blood pressure, and pulse rate.
Mean PRA fell by 50% following L-dopa, which was significantly different from the slight rise which occurred after saline infusion. There was a significant increase in urinary sodium excretion and effective renal plasma flow on infusion of L-dopa. Mean diastolic blood pressure fell during L-dopa infusion, in contrast to the slight increase which occurred during the control study.
These observations confirm the anticipated renal dopaminergic effects of L-dopa and also suggest a dopaminergic influence on renin release in man.
Similar content being viewed by others
References
Baines AD, Chan W (1980) Production of urine free dopamine from DOPA: A micropuncture study — Life Sci 26: 253–259
Baines AD, Graan A, Chan W, Morgunov N (1979) Tubular secretion and metabolism of dopamine, norepinephrine, methyoxytyramine and normetanephrine by the rat kidney. J Pharmacol Exp Ther 208: 144–147
Ball SG, Gunn IG, Douglas IHS (1982) Renal handling of dopa, dopamine, norepinephrine and epinephrine in the dog. Am J Physiol 242: F56-F62
Bell C, Lang WJ (1973) Neural dopaminergic vasodilator control in the kidney. Nature N Biol 246: 27–29
Bello-Reuss E, Higashi Y, Kaneda Y (1982) Dopamine decreases fluid reabsorption in straight portions of rabbit proximal tubule. Am J Physiol 242: F634-F640
Blair M, Reid IA, Ganong WF (1977) Effect of L-dopa on plasma renin activity with and without inhibition of extracerebral dopa decarboxylase in dogs. J Pharmacol Exp Ther 202: 209–215
Boshes B (1981) Sinemet and the treatment of Parkinsonism. Ann Intern Med 94: 364–370
da Prada M, Zürcher G (1976) Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range. Life Sci 19: 1161–1174
Dinerstein RJ, Vannice J, Henderson RC, Roth LJ, Goldberg LI Hoffmann PC (1979) Histofluorescent evidence for dopamine-containing neuronal elements in canine kidney. Science 205: 497–499
D'Orio V, El Allaf D, Juchmes J, Marcelle R (1984) The use of low doses of dopamine in intensive care medicine. Arch Int Physiol Biochim 92: S11-S20
Dzau VJ, Siwek LG, Barger AC (1978) Intrarenal DA-receptors in control of renin release in the conscious dog. Fed Proc 37: 901
Felder RA, Blecher M, Cakagno PL, Jose PA (1984) Dopamine receptors in the proximal tubule of the rabbit. Am J Physiol 247: F499-F505
Goldberg LI (1972) Cardiovascular and renal actions of dopamine: Potential clinical applications. Pharmacol Rev 24: 1–28
Haber E, Koerner T, Page LB, Kliman B, Purnode A (1969) Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab 29: 1349–1355
Hagege J, Richet G (1985) Proximal tubule dopamine histofluorescence in renal slices incubated with L-dopa. Kidney Int 27: 3–8
Harries JD, Mildenberger RR, Malowany AS, Drummond KN (1972) A computerised cumulative integral method for the precise measurement of the glomerular filtration rate. Proc Soc Exp Biol Med 140: 1148–1155
Henry DP, Aoi W, Weinberger MH (1977) The effects of dopamine on renin release in vitro. Endocrinology 101: 279–283
Hilberman M, Moseda J, Stinson EB, Derby GC, Spencer RJ, Miller DC, Oyer PE, Myers BD (1984) The diuretic properties of dopamine in patients after open-heart operation. Anesthesiology 61: 489–494
Holland OB, Thomas C, Brown H, Schindewolf D, Hillier Y, Gomez-Sanchez C (1983) Aldosterone suppression with dopamine infusion in low-renin hypertension. J Clin Invest 72: 754–766
Jeffrey RF, MacDonald TM, Marwick K, Lee MR (1988) The effect of carbidopa and indomethacin on the renal response to γ-L-glutamyl-L-dopa in normal man. Br J Clin Pharmacol 25: 195–201
Judy WV, Watanabe AM, Henry DP (1978) Effect of L-dopa on sympathetic nerve activity and blood pressure in the spontaneously hypertensive rat. Circ Res 43: 24–28
Keeton TK, Campbell WB (1984) The pharmacologic alteration of renin release. Pharmacol Rev 32: 81–227
Kikuchi K, Miyama A, Nakas T, Takigami Y, Kondo A, Mito T, Ura N, Tsuzuki M, Irinura O (1982) Haemodynamic and natriuretic responses to intravenous infusion of dopamine in patients with essential hypertension. Jap Circ J 46: 486–493
Koyama S, Sasaki M, Setoyama T, Takahashi K, Togashi K, Suzuki K, Kakki N, Imai M (1985) Dopaminergic modulation of the renal effect of arginine-vasopressin in water-loaded rats. Jap J Pharmacol 38: 25–30
Langard O (1984) Haemodynamic and adrenergic mechanisms for renin release. J Oslo City Hosp 34: 91–102
Levinson PD, Goldstein DS, Murson PJ, Gill JR, Keiser HR (1985) Endocrine, renal and haemodynamic responses to graded dopamine infusions in normal men. J Clin Endocrinol Metab 60: 821–826
Lightman SL (1981) Studies on the responses of plasma renin activity and aldosterone and cortisol levels to dopaminergic and opiate stimuli in man. Clin Endocrinol 15: 45–52
McDonald TM, Jeffrey RJ, Freestone S, Lee MR (1987) D-sulpiride antagonises the renal effects of γ-L-glutamyl-L-dopa in man. Br J Clin Pharmacol 23: 612–613
Otsuka K, Assaykeen TA, Goldfien A, Ganong WF (1970) Effect of hypoglycaemia on plasma renin activity in dogs. Endocrinology 87: 1306–1317
Wilcox CS, Aminoff MJ, Kurtz AB, Slater JDH (1974) Comparison of the renin response to dopamine and noradrenaline in normal subjects and patients with autonomic insufficiency. Clin Sci 46: 481–488
Williams BC, Eglen A, Duncan FM, Edwards CRW (1985) The effect of sodium intake on the renin response to dopamine in superfused rat renal cortical cells. J Hypertens 3 (S3): S267-S268
Worth DP, Harvey JN, Brown J, Lee MR (1985a) γ-L-glutamyl-L-dopa is a dopamine pro-drug, relatively specific for the kidney in normal subjects. Clin Sci 69: 207–214
Worth DP, Harvey JN, Brown J, Lee MR (1985b) Patients with essential hypertension have an exaggerated natriuretic response to the dopamine pro-drug glutamyl dopa. J Hypertens 3 (S3): S179-S181
Worth DP, Harvey JN, Brown J, Lee MR (1986) Domperidone treatment in man inhibits the fall in plasma renin activity induced by intravenous γ-L-glutamyl-L-dopa. Br J Clin Pharmacol 21: 497–502
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Worth, D., Harvey, J., Brown, J. et al. The effects of intravenous L-dopa on plasma renin activity, renal function, and blood pressure in man. Eur J Clin Pharmacol 35, 137–141 (1988). https://doi.org/10.1007/BF00609242
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00609242