Summary
A case of adrenoleukodystrophy was studied morphologically and biochemically. The patient was a 28-year-old man with no family history of adrenoleukodystrophy. His neurologic symptoms were cerebellar ataxia, spastic paraplegia, pseudo-bulbar palsy, and a minimal visual disturbance, with neither adrenal nor hypogonadal symptoms.
The morphological and biochemical findings in this case are identical with those in typical adrenoleukodystrophy, but the topographical distribution of the lesions is distinctly different. The changes selectively affect the white matter in the cerebellum and brain stem in contrast to minimal involvement of the occipital white matter.
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Kuroda, S., Hirano, A. & Yuasa, S. Adrenoleukodystrophy-cerebello-brainstem dominant case. Acta Neuropathol 60, 149–152 (1983). https://doi.org/10.1007/BF00685361
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DOI: https://doi.org/10.1007/BF00685361