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Prevention of p.o. clotting of av. cimino fistulae with Acetylsalicyl acid results of a prospective double blind study

Zur Prophylaxe des postoperativen Thromboserisikos von Cimino-Fisteln mit Acetylsalicylsäure

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Summary

In a prospective double blind study prophylactic administration of Acetylsalicylic acid (ASA) in low doses decreased significantly the rate of fistula clotting in the immediately p.o. period in uremic patients. The risk of fistula clotting was related to poor arterial blood flow, female sex and number of unsuccessful previous fistula operations. The incidence of side effects (g.i. and non g.i. bleeding) was acceptable with low doses of ASA and prophylactic administration of antacids.

Zusammenfassung

In einer prospektiven Doppelblindstudie wurde der Einfluß von Acetylsalicylsäure auf die Häufigkeit von Cimino-Fistelthrombosen in der ersten p.o. Phase untersucht. Durch prophylaktische Gabe von Acetylsalicylsäure ließ sich der thrombotische Fistelverschluß auf 4% senken (Placebogruppe: 23%). Ein erhöhtes Thromboserisiko bestand bei schlechtem arteriellen Blutfluß, weiblichem Geschlecht und vorausgegangenen erfolglosen Fisteloperationen. Die Nebenwirkungen von Acetylsalicylsäure waren vertretbar, sofern Aspirin in niedriger Dosierung und in Verbindung mit Antacida verabreicht wurde.

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Literatur

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Authors and Affiliations

  1. Medizinische Universitätsklinik Heidelberg, Germany

    K. Andrassy, H. Malluche, H. Bornefeld, M. Comberg, E. Ritz, H. Jesdinsky & K. Möhring

  2. Zentrum für Innere Medizin Frankfurt, Germany

    K. Andrassy, H. Malluche, H. Bornefeld, M. Comberg, E. Ritz, H. Jesdinsky & K. Möhring

  3. Nephrologische Abteilung Institut für Medizinische Dokumentation und Statistik der Universität Freiburg, Germany

    K. Andrassy, H. Malluche, H. Bornefeld, M. Comberg, E. Ritz, H. Jesdinsky & K. Möhring

  4. Urologische Abteilung der Chirurgischen Universitätsklinik Heidelberg, Germany

    K. Andrassy, H. Malluche, H. Bornefeld, M. Comberg, E. Ritz, H. Jesdinsky & K. Möhring

Authors
  1. K. Andrassy
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  2. H. Malluche
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  3. H. Bornefeld
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  4. M. Comberg
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  5. E. Ritz
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  6. H. Jesdinsky
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  7. K. Möhring
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Additional information

We thank Prof. Hallauer, Karlsruhe, Prof. Klütsch, Würzburg and Prof. Fiegel, Mainz for kindly cooperating in this study.

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Andrassy, K., Malluche, H., Bornefeld, H. et al. Prevention of p.o. clotting of av. cimino fistulae with Acetylsalicyl acid results of a prospective double blind study. Klin Wochenschr 52, 348–349 (1974). https://doi.org/10.1007/BF01468835

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  • DOI: https://doi.org/10.1007/BF01468835

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