Abstract
A case of neuromuscular hyperactivity syndrome associated with a thymoma, high serum titres of anti-acetylcholine receptor and anti-DNA antibodies is reported. The study of peripheral nerve conduction revealed a peripheral neuropathy. Repetitive stimulation showed a decrease in the fifth M response. Myasthenic symptoms were anamnestically reported but were absent at clinical observation. The clinical picture and EMG examination improved after phenytoin administration.
Sommario
È riportato un caso caratterizzato da sindrome da iperattività neuromuscolare associata a timoma, alti titoli di anticorpi anti-recettore dell'acetilcolina e anti-DNA. Lo studio della conduzione del nervo periferico ha evidenziato una neuropatia periferica. La stimolazione ripetitiva ha evidenziato un incremento della V risposta M.
Al momento dell'osservazione clinica non erano presenti sintomi miastenici, riferiti invece anamnesticamente. Sia il quadro clinico che quello elettromiografico sono migliorati dopo somministrazione di fenitoina.
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Perini, M., Ghezzi, A., Basso, P.F. et al. Association of neuromyotonia with peripheral neuropathy, myasthenia gravis and thymoma: A case report. Ital J Neuro Sci 15, 307–310 (1994). https://doi.org/10.1007/BF02339242
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DOI: https://doi.org/10.1007/BF02339242