Abstract
In order to ascertain how widely the Kernohan and WHO numerical grading systems for brain tumours are used in Britain and how uniformly they are applied, a questionnaire was circulated to named neuropathologists in 19 Regional Neuropathology Centres in Britain. Eighty four per cent replied within 10 days. Their replies showed considerable variation in the use of grading systems and revealed that numerical grading was required mainly by clinicians and was not necessarily favoured by pathologists. Although some advantages of a grading system were advanced, it does seem that numerical grading of brain tumours is ill-defined and controversial. Furthermore, the use of historical grading systems may inhibit the incorporation of advances in pathological investigation into the clinical management of patients with brain tumours.
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Burger PC, FS Vogel, SB Green, TA Strike: Glioblastoma Multiforme and Anaplastic Astrocytoma: Pathologic criteria and prognostic implications. Cancer 56 (1985) 1106–1111
Gerdes J, H Lemke, H Baisch, H-H Wacker, U Schwab, H Stein: Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. J Immunol 133 (1984) 1710–1715
Kernohan JW, GP Sayer: Tumors of the Central Nervous System. Armed Forces Institute of Pathology, Washington 1952
Mørk SJ, TB Halvorsen, K-F Lindegaard, GE Eire: Oligodendroglioma. Histologic Evaluation and Prognosis. J Neuropathol Exp Neurol 45 (1986) 65–78
Raghavan R, P Steart, RO Weller: Cell proliferation patterns in the diagnosis of astrocytomas, anaplastic astrocytomas and glioblastoma multiforme: a Ki-67 study Neuropathol Appl Neurobiol 16 (1990) 123–133
Rorke LB: The cerebellar medulloblastoma and its relationship to Primitive Neuroectodermal Tumors. J Neuropath Exp Neurol 42 (1983) 1–15
Runinstein LJ: Immunohistochemical signposts — not markers — in neural tumour differentiation. Neuropathol Appl Neurobiol 12 (1986) 523–537
Weller RO, JS Garfield: Long survival in adult patients with tumours exhibiting neuronal differentiation. Clin Neuropathol 5 (1989) 255
Zülch KJ: Histological Typing of Tumours of the Central Nervous System — International Histological Classification of Tumours. World Health Organization, Geneva (1979)
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Weller, R.O. Grading of brain tumours. The British experience. Neurosurg. Rev. 15, 7–11 (1992). https://doi.org/10.1007/BF02352059
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DOI: https://doi.org/10.1007/BF02352059