Abstract
Rationale
Depression is a frequent non-motor symptom in Parkinson’s disease (PD) with increasing rates with the progression of the disease. Molecular imaging studies have shown a reduction of dopamine transporter (DAT) density in depressed PD patients (dPD); however, DAT role in the pathophysiology of PD depression is not clear since clinical matching was inappropriate and DAT reduction could be attributed to PD severity.
Objectives
To further examine the role of DAT in PD depression, this study compared thoroughly matched depressed vs. non-depressed PD patients (ndPD).
Materials and methods
Twenty PD patients (n = 10 ndPD; n = 10 dPD) matched for age and disease severity were submitted to brain SPECT imaging with [99mTc]-TRODAT-1, a DAT radioligand. DAT-binding potential was calculated using regions of interest bilaterally drawn in the striatum, caudate, and putamen. Depression was defined according to Beck Depression Inventory (BDI; cut-off >18).
Results
Mean BDI scores were higher in dPD (25.0 ± 5.6) than in ndPD patients (8.0 ± 1.9, p < 0.0001). DAT density was greater on dPD especially in the left caudate (dPD 0.87 ± 0.19 vs. ndDP 0.69 ± 0.18, p = 0.02) and right putamen (dPD 0.37 ± 0.07 vs. ndPD 0.28 ± 0.13, p = 0.03) than in ndPD patients.
Conclusion
Our results suggest that in vivo DAT density is increased in dPD patients as compared to ndPD, suggesting that DAT is implicated in the pathophysiology of PD depression.
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References
Argyelan M, Szabo Z, Kanyo B, Tanacs A, Kovacs Z, Janka Z, Pavics L (2005) Dopamine transporter availability in medication free and in bupropion treated depression: a 99mTc-TRODAT-1 SPECT study. J Affect Disord 89:115–123
Bressan RA, Shih MC, Hoexter MQ, Lacerda AL (2007) Can molecular imaging techniques identify biomarkers for neuropsychiatric disorders? Rev Bras Psiquiatr 29:102–104
Broussolle E, Dentresangle C, Landais P, Garcia-Larrea L, Pollak P, Croisile B, Hibert O, Bonnefoi F, Galy G, Froment JC, Comar D (1999) The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson’s disease. J Neurol Sci 166:141–151
Brunswick DJ, Amsterdam JD, Mozley PD, Newber A (2003) Greater availability of brain dopamine transporters in major depression shown by [99mTc]TRODAT-1 SPECT imaging. Am J Psychiatry 160:1836–1841
Felicio AC, Godeiro-Junior C, Shih MC, Borges V, Silva SM, Aguiar PD, Hoexter MQ, Barsottini OG, Andrade LA, Bressan RA, Ferraz HB (2010) Evaluation of patients with clinically unclear Parkinsonian syndromes submitted to brain SPECT imaging using the technetium-99 m labeled tracer TRODAT-1. J Neurol Sci 291:64–68
Hesse S, Meyer PM, Strecker K, Barthel H, Wegner F, Oehlwein C, Isaias IU, Schwarz J, Sabri O (2009) Monoamine transporter availability in Parkinson’s disease patients with or without depression. Eur J Nucl Med Mol Imaging 36:428–435
Koerts J, Leenders KL, Koning M, Portman AT, van Beilen M (2007) Striatal dopaminergic activity (FDOPA-PET) associated with cognitive items of a depression scale (MADRS) in Parkinson’s disease. Eur J Neurosci 25:3132–3136
Laasonen-Balk T, Kuikka J, Viinamaki H, Husso-Saastamoinen M, Lehtonen J, Tiihonen J (1999) Striatal dopamine transporter density in major depression. Psychopharmacology 144:282–285
Lehto SM, Tolmunen T, Kuikka J, Valkonen-Korhonen M, Joensuu M, Saarinen PI, Vanninen R, Ahola P, Tiihonen J, Lehtonen J (2008) Midbrain serotonin and striatum dopamine transporter binding in double depression: a one-year follow-up study. Neurosci Lett 441:291–295
Meyer JH, Krüger S, Wilson AA, Christensen BK, Goulding VS, Schaffer A, Minifie C, Houle S, Hussey D, Kennedy SH (2001) Lower dopamine transporter binding potential in striatum during depression. NeuroReport 12:4121–4125
Murai T, Müller U, Werheid K, Sorger D, Reuter M, Becker T, von Cramon DY, Barthel H (2001) In vivo evidence for differential association of striatal dopamine and midbrain serotonin systems with neuropsychiatric symptoms in Parkinson’s disease. J Neuropsychiatry Clin Neurosci 13:222–228
Rektorova I, Srovnalova H, Kubikova R, Prasek J (2008) Striatal dopamine transporter imaging correlates with depressive symptoms and tower of London task performance in Parkinson’s disease. Mov Disord 23:1580–1587
Remy P, Doder M, Lees A, Turjanski N, Brooks D (2005) Depression in Parkinson’s disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain 128:1314–1322
Rickards H (2005) Depression in neurological disordes: Parkinson’s disease, multiple sclerosis, and stroke. J Neurol Neurosurg Psychiatry 76:48–52
Sarchiapone M, Carli V, Camardese G, Cuomo C, Di Giuda D, Calcagni ML, Focacci C, De Risio S (2006) Dopamine transporter binding in depressed patients with anhedonia. Psychiatry Res 147:243–248
Tumas V, Rodrigues GG, Farias TL, Crippa JA (2008) The accuracy of diagnosis of major depression in patients with Parkinson’s disease: a comparative study among the UPDRS, the geriatric depression scale and the Beck depression inventory. Arq Neuropsiquiatr 66:152–156
Weintraub D, Newberg AB, Cary MS, Siderowf AD, Moberg PJ, Kleiner-Fisman G, Duda JE, Stern MB, Mozley D, Katz IR (2005) Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson’s disease. J Nucl Med 46:227–232
Yang YK, Yeh TL, Yao WJ, Lee IH, Chen PS, Chiu NT, Lu RB (2008) Greater availability of dopamine transporters in patients with major depression—a dual-isotope SPECT study. Psychiatry Res 162:230–235
Acknowledgements
Supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) and the Fondation Philanthropique Edmond J. Safra. Dr. Andre C. Felicio is supported by a scholarship doctorate grant from FAPESP and Dr. Tais S. Moriyama is supported by scholarships from Instituto UNIEMP.
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Felicio, A.C., Moriyama, T.S., Godeiro-Junior, C. et al. Higher dopamine transporter density in Parkinson’s disease patients with depression. Psychopharmacology 211, 27–31 (2010). https://doi.org/10.1007/s00213-010-1867-y
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DOI: https://doi.org/10.1007/s00213-010-1867-y