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MRI appearance of muscle denervation

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Abstract

Muscle denervation results from a variety of causes including trauma, neoplasia, neuropathies, infections, autoimmune processes and vasculitis. Traditionally, the diagnosis of muscle denervation was based on clinical examination and electromyography. Magnetic resonance imaging (MRI) offers a distinct advantage over electromyography, not only in diagnosing muscle denervation, but also in determining its aetiology. MRI demonstrates characteristic signal intensity patterns depending on the stage of muscle denervation. The acute and subacutely denervated muscle shows a high signal intensity pattern on fluid sensitive sequences and normal signal intensity on T1-weighted MRI images. In chronic denervation, muscle atrophy and fatty infiltration demonstrate high signal changes on T1-weighted sequences in association with volume loss. The purpose of this review is to summarise the MRI appearance of denervated muscle, with special emphasis on the signal intensity patterns in acute and subacute muscle denervation.

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References

  1. Aprile I, Padua L, Caliandro P, Pazzaglia C, Tonali P. Peroneal nerve palsy caused by thrombosis of crural veins. Neurology. 2003; 60: 1559–1560.

    Article  CAS  Google Scholar 

  2. Dillin L, Hoaglund FT, Scheck M. Brachial neuritis. J Bone Joint Surg Am 1985; 67: 878–880.

    Article  CAS  Google Scholar 

  3. Greenman RL, Khaodhiar L, Lima C, Dinh T, Giurini M, Veves A. Foot small muscle atrophy is present before the detection of clinical neuropathy. Diabetes Care 2005; 28: 1425–1430.

    Article  Google Scholar 

  4. Antoniadis G, Richter HP, Rath S, Braun V, Moese G. Suprascapular nerve entrapment: experience with 28 cases. J Neurosurg 1996; 85: 1020–1025.

    Article  CAS  Google Scholar 

  5. Berry H, Kong K, Hudson AR, Moulton RJ. Isolated suprascapular nerve palsy: a review of nine cases. Can J Neurol Sci 1995; 22: 301–304.

    Article  CAS  Google Scholar 

  6. Millesi-Eberhard D, Konig B, Millesi H. Compression syndromes of the axillary nerve and the suprascapular nerve. Handchir Mikrochir Plast Chir 1999; 31: 311–316.

    Article  CAS  Google Scholar 

  7. Sofka CM, Lin J, Feinberg J, Potter HG. Teres minor denervation on routine magnetic resonance imaging of the shoulder. Skeletal Radiol 2004; 33: 514–518.

    Article  Google Scholar 

  8. Bredella MA, Tirman PF, Fritz RC, Wischer TK, Stork A, Genant HK. Denervation syndromes of the shoulder girdle: MR imaging with electrophysiologic correlation. Skeletal Radiol 1999; 28: 567–572.

    Article  CAS  Google Scholar 

  9. Gaskin CM, Helms CA. Parsonage-Turner syndrome: MR imaging findings and clinical information of 27 patients. Radiology 2006; 240: 501–507.

    Article  Google Scholar 

  10. Koltzenburg M, Bendszus M. Imaging of peripheral nerve lesions. Curr Opin Neurol 2004; 17: 621–626.

    Article  Google Scholar 

  11. Wessig C, Koltzenburg M, Reiners K, Salmons L, Bendszus M. Muscle magnetic resonance imaging of denervation and reinnervation: correlation with electrophysiology and histology. Exp Neurol 2004; 185: 254–261.

    Article  Google Scholar 

  12. Polak JF, Jolesz FA, Adams DF. Magnetic resonance imaging of skeletal muscle. Prolongation of T1 and T2 subsequent to denervation. Invest Radiol 1988; 23: 365–369.

    Article  CAS  Google Scholar 

  13. Kikuchi Y, Nakamura T, Takayama S, Horiuchi Y, Toyama Y. MR imaging in the diagnosis of denervated and reinnervated skeletal muscles: experimental study in rats. Radiology 2003; 229: 861–867.

    Article  Google Scholar 

  14. Kirsch GE, Anderson MF. Sodium channel kinematics in normal and denervated rabbit muscle membrane. Muscle Nerve 1986; 9: 738–747.

    Article  CAS  Google Scholar 

  15. Clausen T. Regulation of active Na+-K+ transport in skeletal muscle. Physiol Rev 1986; 66: 542–580.

    Article  CAS  Google Scholar 

  16. Shoji S. Effect of denervation on glucose uptake in rat soleus and extensor digitorum longus muscles. Muscle Nerve 1986; 9: 69–72.

    Article  CAS  Google Scholar 

  17. Goldspink DF. The effect of denervation on protein turnover of rat skeletal muscle. Biochem Genet 1976; 156: 71–80.

    Article  CAS  Google Scholar 

  18. Furuno K, Goodman MN, Goldberg AL. Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy. J Biol Chem 1990; 265: 8550–8557.

    CAS  PubMed  Google Scholar 

  19. Jolesz F, Sreter FA. Development, innervation, and activity-pattern induced changes in skeletal muscle. Annu Rev Physiol 1981; 43: 531–552.

    Article  CAS  Google Scholar 

  20. Sarnat HB, Portnoy JM, Chi DYK. Effects of denervation and tenotomy on the gastrocnemius muscle in the frog: a histologic and histochemical study. Anat Rec 1977; 187: 335–346.

    Article  CAS  Google Scholar 

  21. Chor H, Dolkart RE, Davenport HA. Chemical and histological changes in denervated skeletal muscle of the monkey and cat. Am J Physiol 1936; 118: 580–587.

    Article  Google Scholar 

  22. Hines HM, Knowlton GC. Changes in the skeletal muscle of the rat following denervation. Am J Physiol 1933; 104: 379–391.

    Article  CAS  Google Scholar 

  23. Tsubahara A, Chino N, Okajima Y, Akaboshi K. Fat/water suppression magnetic resonance (MR) imaging in disuse muscular atrophy. Neuroorthopedics 1995; 17: 67–74.

    Google Scholar 

  24. Kullmer K, Sievers KW, Reimers CD, et al. Changes of sonographic, magnetic resonance tomographic, electromyographic, and histopathologic findings within a 2-month period of examinations after experimental muscle denervation. Arch Orthop Trauma Surg 1998; 117: 228–234.

    Article  CAS  Google Scholar 

  25. Bendszus M, Koltzenburg M, Wessig C, Solymosi L. Sequential MR imaging of denervated muscle: experimental study. AJNR Am J Neuroradiol 2002; 23: 1427–1431.

    PubMed  Google Scholar 

  26. West GA, Haynor DR, Goodkin R, et al. Magnetic resonance imaging signal changes in denervated muscles after peripheral nerve injury. Neurosurgery 1994; 35: 1077–1085.

    Article  CAS  Google Scholar 

  27. Shabas D, Gerard G, Rossi D. Magnetic resonance imaging examination of denervated muscle. Comput Radiol 1987; 11: 9–13.

    Article  CAS  Google Scholar 

  28. Fleckenstein JL, Watumull D, Conner KE, et al. Denervated human skeletal muscle: MR imaging evaluation. Radiology 1993; 187: 213–218.

    Article  CAS  Google Scholar 

  29. Uetani M, Hayashi K, Matsunaga N, Imamura K, Ito N. Denervated skeletal muscle: MR imaging. Work in progress. Radiology 1993; 189: 511–515.

    Article  CAS  Google Scholar 

  30. Bendszus M, Koltzenburg M. Visualization of denervated muscle by gadolinium-enhanced MRI. Neurology 2001; 57: 709–1711.

    Article  CAS  Google Scholar 

  31. Kato K, Tomura N, Takahashi S, Watarai J. Motor denervation of tumors of the head and neck: changes in MR appearance. Magn Reson Med Sci 2002; 1: 157–164.

    Article  Google Scholar 

  32. Tews DS, Goebel HH, Schneider I, Gunkel A, Stennert E, Neiss WF. Morphology of experimentally denervated and reinnervated rat facial muscle. I. Histochemical and histological findings. Eur Arch Otorhinolaryngol 1994; 251: 36–40.

    Article  CAS  Google Scholar 

  33. Petersilge CA, Pathria MN, Gentili A, Recht MP, Resnick D. Denervation hypertrophy of muscle: MR features. J Comput Assist Tomogr 1995; 19: 596–600.

    Article  CAS  Google Scholar 

  34. Dort JC, Zochodne D, Fan Y, Prychitko J, Peeling J. Biochemical changes in denervated muscle identified by magnetic resonance spectroscopy. J Otolaryngol 1997; 26: 368–373.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, University Hospital of Wales, Heath Park, Cardiff, CF14 4XW, UK

    S. Kamath

  2. Department of Radiology, Derriford Hospital, Plymouth, PL6 8DH, UK

    N. Venkatanarasimha, M. A. Walsh & P. M. Hughes

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  1. S. Kamath
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  2. N. Venkatanarasimha
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  3. M. A. Walsh
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  4. P. M. Hughes
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Correspondence to S. Kamath.

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Kamath, S., Venkatanarasimha, N., Walsh, M.A. et al. MRI appearance of muscle denervation. Skeletal Radiol 37, 397–404 (2008). https://doi.org/10.1007/s00256-007-0409-0

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  • DOI: https://doi.org/10.1007/s00256-007-0409-0

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