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Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD

A comparison of neuropsychological effects

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Abstract

Objective

To compare the cognitive and behavioural effects of unilateral pallidotomy and bilateral subthalamic nucleus (STN) stimulation.

Methods

After baseline examination 34 patients were randomly assigned to unilateral pallidotomy (4 left-sided, 10 right-sided) or bilateral STN stimulation (n=20). At baseline and six and twelve months after surgery we administered neuropsychological tests of language, memory, visuospatial function, mental speed and executive functions. Also a depression rating scale, and self and proxy ratings of memory and dysexecutive symptoms were administered.

Results

Six months after surgery, the STN group and the pallidotomy group differed significantly in change from baseline in number of errors on two tests of executive functioning. After 12 months the STN group reported less positive affect compared with baseline than the pallidotomy group. One patient in the STN group showed an overall cognitive deterioration due to complications.

Conclusions

Although we need larger groups to draw firm conclusions, our results suggest that bilateral STN stimulation has slightly more negative effects on executive functioning than unilateral pallidotomy.

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Authors and Affiliations

  1. Dept. of Neurology, H2–222, Academic Medical Center, 22660, 1100, DD Amsterdam, The Netherlands

    Harriet M. M. Smeding MSc, Rianne A. J. Esselink MD, Ben Schmand PhD & Johannes D. Speelman PhD

  2. Dept. of Neurology, University Hospital, Groningen, The Netherlands

    Marthe Koning-Haanstra MSc

  3. Dept. of Medical Psychology, Medical Spectrum, Twente, The Netherlands

    Ilse Nijhuis MSc

  4. Dept. of Neurology, Sint Elisabeth Hospital, Tilburg, The Netherlands

    Elze M. Wijnalda MSc

Authors
  1. Harriet M. M. Smeding MSc
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  2. Rianne A. J. Esselink MD
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  3. Ben Schmand PhD
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  4. Marthe Koning-Haanstra MSc
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  5. Ilse Nijhuis MSc
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  7. Johannes D. Speelman PhD
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Correspondence to Harriet M. M. Smeding MSc.

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Smeding, H.M.M., Esselink, R.A.J., Schmand, B. et al. Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD. J Neurol 252, 176–182 (2005). https://doi.org/10.1007/s00415-005-0628-z

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  • DOI: https://doi.org/10.1007/s00415-005-0628-z

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