Skip to main content

Advertisement

SpringerLink
Log in

Characteristics of Devic's disease (neuromyelitis optica) in Mexico

  • ORIGINAL COMMUNICATION
  • Published:
Journal of Neurology Aims and scope Submit manuscript

Abstract

Objective

To report clinical and epidemiological data of Devic's disease in Mexico.

Design

Retrospective study of hospital case records.

Setting

The medical records were those of the National Institute for Neurology and Neurosurgery (INNN), a tertiary care referral center in Mexico City.

Patients

There were 424 medical histories available for review among 561 discharges with diagnoses of multiple sclerosis (MS), neuromyelitis optica (NMO), or equivalents. 390 met the diagnostic criteria of MS and 34 the NMO criteria.

Main outcome measures

We recorded clinical signs, visual acuities, and the Expanded Disability Status Scale (EDSS) at the initial diagnostic admission and during follow-up. All patients had examination of cerebrospinal fluid (CSF) at diagnosis; head and spine magnetic resonance imaging (MRI) were performed at diagnosis and at follow-up.

Results

All 34 patients were Mexican Mestizos, who comprise 79 % of the residents of Mexico City. There were 23 monophasic and 11 relapsing cases. Intervals between initial and defining events for the 8 ON and 12 myelitis onsets were 17 and 24 months (means) and 15 and 17 months (medians), respectively. Mean follow- up from onset was 70.2 months and 42.9 months from diagnostic examination. No patient showed improvement in EDSS scores. Visual loss was severe.

Conclusion

A provisional prevalence rate of about 1 per 100,000 population for NMO in Mexican Mestizos might be offered. The disease seems more severe in our population than in other recent series.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Arruda WO, Scola RH, Teive HA, Werneck LC (2001) Multiple sclerosis: report of 200 cases from Curitiba, southern Brazil and comparison with other Brazilian series. Arq Neuropsiquiatr 59:165–170

    PubMed  CAS  Google Scholar 

  2. Cabre P, Heinzlef O, Merle H, Buisson GG, Bera O, Bellance R (2001) MS and neuromyelitis optica in Martinique (French West Indies). Neurology 56:507–514

    PubMed  CAS  Google Scholar 

  3. Corona T, Roman GC (2006) Multiple sclerosis in Latin America. Neuroepidemiology 26:1–3

    Article  PubMed  Google Scholar 

  4. Devic (1894) Thèse Gault, Lyon. Congrès de Médicine Inter. 1re session, Lyon (cited by Gault [6])

  5. Fazekas F, Offenbacher H, Schmidt R, Strasser-Fuchs S (1994) MRI of neuromyelitis optica: evidence for a distinct entity (letter). J Neurol Neurosurg Psychiatr 57:1140–1142

    Article  PubMed  CAS  Google Scholar 

  6. Gault F (1894) De La Neuromyélite Optique Aiguë. Thèse. Lyon; Alexandre Rey, Imprimeur de la Faculté de Médicine. Novembre 1894 (p 104)

  7. Ghezzi A, Bergamaschi R, Martinelli V, Trojano M, Tola MR, Merelli E (2004) Clinical characteristics, course and prognosis of relapsing Devic's neuromyelitis optica. J Neurol 251:47–52

    Article  PubMed  Google Scholar 

  8. Guthrie TC, Kurtzke JF, Berlin L (1952) Acute respiratory failure in multiple sclerosis and its management. Ann Int Med 37:1197–1203

    PubMed  CAS  Google Scholar 

  9. Jacobs D, Roemer S, Weinshenker B, Pittock S, Wingerchuk D, Lennon V, Lucchinetti CF (2006) The pathology of brain involvement in neuromyelitis optica spectrum disorders. Mult Scler 12:S155 (abstract)

    Google Scholar 

  10. Kuroiwa Y, Igata A, Itahara K, Koshijima S, Tsubaki T, Toyokura Y (1975) Nationwide survey of multiple sclerosis in Japan. Clinical analysis of 1, 084 cases. Neurology 25:845–851

    PubMed  CAS  Google Scholar 

  11. Kurtzke JF (1970) Clinical manifestations of multiple sclerosis. In: Vinken PJ, Bruyn GW (eds) Handbook of clinical neurology. North-Holland Publ Co, Amsterdam, pp 161–216

  12. Kurtzke JF (1975) A reassessment of the distribution of multiple sclerosis. Part one. Acta Neurol Scand 51:110–136

    Article  PubMed  CAS  Google Scholar 

  13. Kurtzke JF (1983) Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444–1452

    PubMed  CAS  Google Scholar 

  14. Lennon VA, Hinson SR (2006) A serum autoantibody marker that identifies neuromyelitis optica. Biomarkers in MS. Basic and clinical issues in multiple sclerosis research. ACTRIMS 11th Annual Meeting, Chicago, IL, p 11

  15. Lennon VA, Kryzer TJ, Pittock SJ, Verkmann AS, Hinson S (2005) IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 202:473–477

    Article  PubMed  CAS  Google Scholar 

  16. Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K (2004) A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 364:2106–2112

    Article  PubMed  CAS  Google Scholar 

  17. Mandler RN, Davis LE, Jeffery DR, Korn feld M (1993) Devic's neuromyelitis optica: a clinicopathological study of 8 patients. Ann Neurol 34:162–168

    Article  PubMed  CAS  Google Scholar 

  18. Nelson LM, McGuire VM (2004) Study design, measures of effect, and sources of bias. In: Nelson LM, Tanner CM, Van Den Eeden SK, McGuire VM (eds) Neuroepidemiology. From Principles to Practice. Oxford University Press, Oxford, pp 23–54

  19. O'Riordan JI, Gallagher HL, Thompson AJ, Howard RS, Miller DH (1996) Clinical, CSF and MRI findings in Devic's neuromyelitis optica. J Neurol Neurosurg Psychiatr 60:382–387

    PubMed  Google Scholar 

  20. Papais-Alvarenga RM, Miranda-Santos CM, Puccioni-Sohler M, de Almeida AMV, Oliveira S, Basilio De Oliveira CA, et al. (2002) Optic neuromyelitis syndrome in Brazilian patients. J Neurol Neurosurg Psychiatry 73:429–435

    Article  PubMed  CAS  Google Scholar 

  21. Patrucco LB, Cristiano E, Videla GC, Bauso Toselli PL (2002) Devic's neuromyelitis optica (NMO) and multiple sclerosis (MS): clinical and epidemiologic findings in an MS center in Argentina. Multiple Sclerosis 8(Suppl):S37 (abstract)

    Google Scholar 

  22. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–231

    Article  PubMed  CAS  Google Scholar 

  23. Reindl M, Khalil M, Berger T (2006) Antibodies as biological markers for pathophysiological processes in MS. J Neuroimmunol 180:50–62

    Article  PubMed  CAS  Google Scholar 

  24. Scolding N (2001) The differential diagnosis of multiple sclerosis. Neurology in Practice 71(Suppl 2):9–15

    Google Scholar 

  25. Scolding N (2005) Devic's disease and autoantibodies. Lancet Neurology 4:136–137

    PubMed  Google Scholar 

  26. Singhal BS (1985) Multiple sclerosis – Indian experience. Ann Acad Med, Singapore 14:32–36

    CAS  Google Scholar 

  27. Wingerchuk DM, Hogancamp WF, O'Brien PC, Weinshenker BG (1999) The clinical course of neuromyelitis optica (Devic's syndrome). Neurology 53:1107–1114

    PubMed  CAS  Google Scholar 

  28. Wingerchuk DM, Lennon VA, Pittock SS, Lucchinetti CF, Weinshenker BG (2006) Revised diagnostic criteria for neuromyelitis optica. Neurology 66:1485–1489

    Article  PubMed  CAS  Google Scholar 

  29. Wright JW (2006) In: Wright J (ed) The New York Times 2006 Almanac. New York, Penguin Books, pp 630–631

Download references

Author information

Authors and Affiliations

  1. Dept. of Neurology, National Institute of Neurology and Neurosurgery, Insurgentes sur 3877, Mexico City, CP 14362, Mexico

    J. F. Rivera MD, V. J. A. Booth MD & T. Corona V. MD

  2. Professor Emeritus of Neurology, Georgetown University, Washington, DC, USA

    J. F. Kurtzke MD, FACP, FAAN

Authors
  1. J. F. Rivera MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. J. F. Kurtzke MD, FACP, FAAN
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. J. A. Booth MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Corona V. MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to T. Corona V. MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rivera, J.F., Kurtzke, J.F., Booth, V.J.A. et al. Characteristics of Devic's disease (neuromyelitis optica) in Mexico. J Neurol 255, 710–715 (2008). https://doi.org/10.1007/s00415-008-0781-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-008-0781-2

Key words

Search

Navigation