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NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease

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References

  1. Dalmau J, Tuzun E, Wu HY, Masjuan J, Rossi JE, Voloschin A, Baehring JM, Shimazaki H, Koide R, King D, Mason W, Sansing LH, Dichter MA, Rosenfeld MR, Lynch DR (2007) Paraneoplastic anti-N-methyl-d-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 61:25–36

    Article  PubMed  CAS  Google Scholar 

  2. Flanagan EP, McKeon A, Lennon VA, Boeve BF, Trenerry MR, Tan KM, Drubach DA, Josephs KA, Britton JW, Mandrekar JN, Lowe V, Parisi JE, Pittock SJ (2010) Autoimmune dementia: clinical course and predictors of immunotherapy response. Mayo Clin Proc 85:881–897

    Article  PubMed  Google Scholar 

  3. Geschwind MD, Tan KM, Lennon VA, Barajas RF Jr, Haman A, Klein CJ, Josephson SA, Pittock SJ (2008) Voltage-gated potassium channel autoimmunity mimicking creutzfeldt-jakob disease. Arch Neurol 65:1341–1346

    Article  PubMed  Google Scholar 

  4. Spencer MD, Knight RS, Will RG (2002) First hundred cases of variant Creutzfeldt-Jakob disease: retrospective case note review of early psychiatric and neurological features. BMJ (Clinical research ed) 324:1479–1482

    Article  Google Scholar 

  5. Irani SR, Bera K, Waters P, Zuliani L, Maxwell S, Zandi MS, Friese MA, Galea I, Kullmann DM, Beeson D, Lang B, Bien CG, Vincent A (2010) N-methyl-d-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 133:1655–1667

    Article  PubMed  Google Scholar 

  6. Irani SR, Vincent A (2011) NMDA receptor antibody encephalitis. Curr Neurol Neurosci Rep. doi:10.1007/s11910-011-0186-y

    PubMed  Google Scholar 

  7. Sassoon J, Daniels M, Brown DR (2004) Astrocytic regulation of NMDA receptor subunit composition modulates the toxicity of prion peptide PrP106-126. Mol Cell Neurosci 25:181–191

    Article  PubMed  CAS  Google Scholar 

  8. Ratte S, Prescott SA, Collinge J, Jefferys JG (2008) Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD. Neurobiol Dis 32:96–104

    Article  PubMed  CAS  Google Scholar 

  9. Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R (2011) Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 10:63–74

    Article  PubMed  CAS  Google Scholar 

  10. Ferrer I, Puig B (2003) GluR2/3, NMDAepsilon1 and GABAA receptors in Creutzfeldt-Jakob disease. Acta Neuropathol 106:311–318

    Article  PubMed  CAS  Google Scholar 

  11. Murray K (2011) Creutzfeldt-Jacob disease mimics, or how to sort out the subacute encephalopathy patient. Pract Neurol 11:19–28

    Article  PubMed  Google Scholar 

  12. Dalmau J, Gleichman AJ, Hughes EG, Rossi JE, Peng X, Lai M, Dessain SK, Rosenfeld MR, Balice-Gordon R, Lynch DR (2008) Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 7:1091–1098

    Article  PubMed  CAS  Google Scholar 

  13. The National CJD surveillance unit (2011) Current data. http://www.cjd.ed.ac.uk. Accessed 22.9.11

  14. Appleby BS, Appleby KK, Crain BJ, Onyike CU, Wallin MT, Rabins PV (2009) Characteristics of established and proposed sporadic Creutzfeldt-Jakob disease variants. Arch Neurol 66:208–215

    Article  PubMed  Google Scholar 

  15. Kovanen J (1993) Clinical characteristics of familial and sporadic Creutzfeldt-Jakob disease in Finland. Acta Neurol Scand 87:469–474

    Article  PubMed  CAS  Google Scholar 

  16. Will RG, Matthews WB (1984) A retrospective study of Creutzfeldt-Jakob disease in England and Wales 1970–79. I: clinical features. J Neurol Neurosurg Psychiatry 47:134–140

    Article  PubMed  CAS  Google Scholar 

  17. Green A, Sanchez-Juan P, Ladogana A, Cuadrado-Corrales N, Sanchez-Valle R, Mitrova E, Stoeck K, Sklaviadis T, Kulczycki J, Heinemann U, Hess K, Slivarichova D, Saiz A, Calero M, Mellina V, Knight R, van Duijn CM, Zerr I (2007) CSF analysis in patients with sporadic CJD and other transmissible spongiform encephalopathies. Eur J Neurol 14:121–124

    Article  PubMed  CAS  Google Scholar 

  18. Zerr I, Kallenberg K, Summers DM, Romero C, Taratuto A, Heinemann U, Breithaupt M, Varges D, Meissner B, Ladogana A, Schuur M, Haik S, Collins SJ, Jansen GH, Stokin GB, Pimentel J, Hewer E, Collie D, Smith P, Roberts H, Brandel JP, van Duijn C, Pocchiari M, Begue C, Cras P, Will RG, Sanchez-Juan P (2009) Updated clinical diagnostic criteria for sporadic Creutzfeldt-Jakob disease. Brain 132:2659–2668

    Article  PubMed  CAS  Google Scholar 

  19. Heath CA, Cooper SA, Murray K, Lowman A, Henry C, MacLeod MA, Stewart GE, Zeidler M, MacKenzie JM, Ironside JW, Summers DM, Knight RS, Will RG (2010) Validation of diagnostic criteria for variant Creutzfeldt-Jakob disease. Ann Neurol 67:761–770

    Article  PubMed  Google Scholar 

  20. Heath CA (2008) Thesis: clinical aspects of variant CJD in the UK: 1995–2005. University of Aberdeen, Aberdeen, pp 1–279

  21. Collie DA, Summers DM, Sellar RJ, Ironside JW, Cooper S, Zeidler M, Knight R, Will RG (2003) Diagnosing variant Creutzfeldt-Jakob disease with the pulvinar sign: MR imaging findings in 86 neuropathologically confirmed cases. Ajnr 24:1560–1569

    PubMed  Google Scholar 

  22. Binelli S, Agazzi P, Giaccone G, Will RG, Bugiani O, Franceschetti S, Tagliavini F (2006) Periodic electroencephalogram complexes in a patient with variant Creutzfeldt-Jakob disease. Ann Neurol 59:423–427

    Article  PubMed  Google Scholar 

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Acknowledgments

The National CJD research and surveillance unit is funded by the Department of Health and the Scottish Government. We are grateful for a remarkable level of cooperation from clinicians across the UK. We are grateful to the relatives of these patients for their permission to publish their cases reports. SRI was supported by the National Institute for Health Research (NIHR), Department of Health, UK, and AV receives funding from the NIHR Oxford Biomedical Research Centre.

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. National CJD Research and Surveillance Unit, Edinburgh, UK

    Graham Mackay, Richard Knight & Robert Will

  2. Department of Neurology, Western General Hospital, Edinburgh, UK

    Kate Ahmad, Jon Stone & Cathie Sudlow

  3. Department of Neuroradiology, Western General Hospital, Edinburgh, UK

    David Summers

  4. Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, Oxford, UK

    Sarosh R. Irani & Angela Vincent

  5. Nottingham University Hospitals NHS Trust, Nottingham, UK

    Paul Maddison

Authors
  1. Graham Mackay
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  2. Kate Ahmad
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  3. Jon Stone
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  4. Cathie Sudlow
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  5. David Summers
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  6. Richard Knight
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  7. Robert Will
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  8. Sarosh R. Irani
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  9. Angela Vincent
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  10. Paul Maddison
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Corresponding author

Correspondence to Graham Mackay.

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Mackay, G., Ahmad, K., Stone, J. et al. NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease. J Neurol 259, 1979–1981 (2012). https://doi.org/10.1007/s00415-012-6489-3

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  • DOI: https://doi.org/10.1007/s00415-012-6489-3

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