Abstract
Serum neuron-specific enolase (s-NSE) and s-100 protein (s-100) are sensitive markers of various brain diseases. We investigated both of these markers in nine patients within 5 min, 6 h, 12 h, and 48 h after a single tonic-clonic seizure. The mean peak s-NSE level was significantly higher after 5 min (11.97 ± 8.56 μg/l) and 48 h (10.31 ± 8.92 μg/l, P < 0.05) than the levels of seizure-free, age-matched controls. Five patients had increased s-NSE levels regarding the upper limit of normal as mean + 3 SD. s-100 was not detected either in controls or epileptic patients. These data indicate that s-NSE in contrast to s-100 may be an in vivo marker after generalized seizures in some patients.
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Received: 2 April 1997 Received in revised form: 22 September 1998 Accepted: 4 November 1998
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Büttner, T., Lack, B., Jäger, M. et al. Serum levels of neuron-specific enolase and s-100 protein after single tonic-clonic seizures. J Neurol 246, 459–461 (1999). https://doi.org/10.1007/s004150050383
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DOI: https://doi.org/10.1007/s004150050383