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Unsuccessful intraventricular pentosan polysulphate treatment of variant Creutzfeldt-Jakob disease

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Summary

Pentosan polysulphate, delivered by chronic intraventricular infusion, has been proposed as a potential therapy for human prion disease. The first treated patient is still alive several years after treatment started. Here we describe in detail a case of variant Creutzfeldt-Jakob disease in which this treatment was started at a relatively early stage but had no definite clinical benefit. The patient died from disease progression 16 months after diagnosis and 5 months after pentosan polysulphate treatment was commenced.

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Authors and Affiliations

  1. Department of Clinical Neurosciences and National CJD Surveillance Unit, Western General Hospital, Edinburgh, UK

    I. R. Whittle, R. S. G. Knight & R. G. Will

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  1. I. R. Whittle
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  2. R. S. G. Knight
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  3. R. G. Will
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Whittle, I., Knight, R. & Will, R. Unsuccessful intraventricular pentosan polysulphate treatment of variant Creutzfeldt-Jakob disease. Acta Neurochir (Wien) 148, 677–679 (2006). https://doi.org/10.1007/s00701-006-0772-y

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  • DOI: https://doi.org/10.1007/s00701-006-0772-y

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